Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR001837 is a Adenylate cyclase-associated CAP.
<p>Cyclase-associated proteins (CAPs) are highly conserved actin-binding proteins present in a wide range of organisms including yeast, fly, plants, and mammals. CAPs are multifunctional proteins that contain several structural domains. CAP is involved in species-specific signalling pathways [[cite:PUB00042568], [cite:PUB00042569], [cite:PUB00042570], [cite:PUB00007159]]. In Drosophila, CAP functions in Hedgehog-mediated eye development and in establishing oocyte polarity. In Dictyostelium (slim mold), CAP is involved in microfilament reorganisation near the plasma membrane in a PIP2-regulated manner and is required to perpetuate the cAMP relay signal to organise fruitbody formation. In plants, CAP is involved in plant signalling pathways required for co-ordinated organ expansion. In yeast, CAP is involved in adenylate cyclase activation, as well as in vesicle trafficking and endocytosis. In both yeast and mammals, CAPs appear to be involved in recycling G-actin monomers from ADF/cofilins for subsequent rounds of filament assembly [[cite:PUB00042579], [cite:PUB00042580]]. In mammals, there are two different CAPs (CAP1 and CAP2) that share 64% amino acid identity.</p> <p>This entry represents CAP proteins from various organisms.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Actin binding | Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. | ||
| Biological process | Cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: adenylyl cyclase-associated protein-like [Cicer arietinum] gi|502149183|ref|XP_004507425.1| | 16 | ||
| – | PREDICTED: adenylyl cyclase-associated protein-like [Cicer arietinum] gi|502149183|ref|XP_004507425.1| | 18 | ||
| – | Adenylyl cyclase-associated protein; TAIR: AT4G34490.1 cyclase associated protein 1; Swiss-Prot: sp|O65902|ACAP1_ARATH Cyclase-associated protein 1; TrEMBL-Plants: tr|I3T3J4|I3T3J4_LOTJA Adenylyl cyclase-associated protein; Found in the gene: LotjaGi1g1v0571000 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |