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IPR017901 is a C-CAP/cofactor C-like domain.
<p>The C-CAP/cofactor C-like domain is present in several cytoskeleton-related proteins, which also contain a number of additional domains [[cite:PUB00026629], [cite:PUB00039797], [cite:PUB00043710], [cite:PUB00043711]]:</p> <ul><li>Eukaryotic cyclase-associated protein (CAP or SRV2), a modular actin monomer binding that directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localisation and the establishment of cell polarity.</li> <li>Vertebrate retinitis pigmentosa 2 (XRP2). In Homo sapiens (Human), it is the protein responsible for X-linked forms of retinitis pigmentosa, a disease characterised by severe retinal degeneration.</li> <li>Eukaryotic tubulin-specific chaperone cofactor C (TBCC), a GTPase- activating component of the tubulin-folding supercomplex, which directs the assembly of the alpha- and beta-tubulin heterodimer.</li></ul> <p>The cyclase-associated protein C-CAP/cofactor C-like domain binds G-actin and is responsible for oligomerisation of the entire CAP molecule [[cite:PUB00026629]], whereas the XRP2 C-CAP/cofactor C-like domain is required for binding of ADP ribosylation factor-like protein 3 (Arl3) [[cite:PUB00039797]].</p> <p>The central core of the C-CAP/cofactor C-like domain is composed of six coils of right-handed parallel β-helices, termed coils 1-6, which form an elliptical barrel with a tightly packed interior. Each β-helical coil is composed of three relatively short β-strands, designated a-c, separated by sharp turns. Flanking the central β-helical core is an N-terminal β-strand, β0, that packs antiparallel to the core, and strand β7 packs antiparallel to the core near the C-terminal end of the parallel β-helix [[cite:PUB00026629], [cite:PUB00039797]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: adenylyl cyclase-associated protein-like [Cicer arietinum] gi|502149183|ref|XP_004507425.1| | 16 | ||
| – | PREDICTED: adenylyl cyclase-associated protein-like [Cicer arietinum] gi|502149183|ref|XP_004507425.1| | 18 | ||
| – | PREDICTED: TBCC domain-containing protein 1-like [Glycine max] gi|356504841|ref|XP_003521203.1| | 12 | ||
| – | PREDICTED: tubulin-folding cofactor C-like [Cicer arietinum] gi|502140152|ref|XP_004504081.1| | 14 | ||
| – | Adenylyl cyclase-associated protein; TAIR: AT4G34490.1 cyclase associated protein 1; Swiss-Prot: sp|O65902|ACAP1_ARATH Cyclase-associated protein 1; TrEMBL-Plants: tr|I3T3J4|I3T3J4_LOTJA Adenylyl cyclase-associated protein; Found in the gene: LotjaGi1g1v0571000 | 21 | ||
| – | TBCC domain-containing protein 1; TAIR: AT3G57890.1 Tubulin binding cofactor C domain-containing protein; Swiss-Prot: sp|A1L0Z4|TBCC1_XENTR TBCC domain-containing protein 1; TrEMBL-Plants: tr|I1JNI6|I1JNI6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0724600 | 13 | ||
| – | Tubulin folding cofactor C, putative; TAIR: AT4G39920.1 C-CAP/cofactor C-like domain-containing protein; Swiss-Prot: sp|Q9SMR2|TBCC_ARATH Tubulin-folding cofactor C; TrEMBL-Plants: tr|A0A072TTR3|A0A072TTR3_MEDTR Tubulin folding cofactor C, putative; Found in the gene: LotjaGi4g1v0396500 | 15 | ||
| – | TBCC domain-containing protein 1; TAIR: AT3G57890.1 Tubulin binding cofactor C domain-containing protein; Swiss-Prot: sp|Q5ZKT1|TBCC1_CHICK TBCC domain-containing protein 1; TrEMBL-Plants: tr|I1JNI7|I1JNI7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0142700 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 12.50 |