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IPR016098 is a Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal.
<p>Cyclase-associated proteins (CAPs) are highly conserved monomeric actin-binding proteins present in a wide range of organisms including yeast, fly, plants, and mammals. CAPs are multifunctional proteins that contain several structural domains. CAP is involved in species-specific signalling pathways [[cite:PUB00042568], [cite:PUB00042569], [cite:PUB00042570], [cite:PUB00007159]]. Only yeast CAPs are involved in adenylate cyclase activation. The C-terminal domain of CAP proteins is responsible for G-actin-binding that regulates actin remodelling in response to cellular signals and is required for normal cellular morphology, cell division, growth and locomotion in eukaryotes.</p> <p>In Escherichia coli, three Min proteins (MinC, MinD and MinE) negatively regulate FtsZ assembly at the cell poles in order to ensure the Z-ring only assembles at cell midpoint. MinC inhibits formation of the Z-ring by preventing FtsZ assembly. MinD binds to MinC near the cell poles, sequestering MinC away from the cell midpoint so the Z-ring can form there. MinC is an oligomer, probably a dimer, that consists of two domains: the N-terminal domain is responsible for FtsZ inhibition, while the C-terminal domain is responsible for binding to MinD and to a component of the division septum [[cite:PUB00008426], [cite:PUB00042573]].</p> <p>This entry represents a structural domain found at the C-terminal of CAP proteins as well as MinC. This domain has a superhelical structure, where the superhelix turns are made of either two (CAP) or three (MinC) β-strands each.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Cell morphogenesis | The developmental process in which the size or shape of a cell is generated and organized. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: adenylyl cyclase-associated protein-like [Cicer arietinum] gi|502149183|ref|XP_004507425.1| | 16 | ||
| – | PREDICTED: adenylyl cyclase-associated protein-like [Cicer arietinum] gi|502149183|ref|XP_004507425.1| | 18 | ||
| – | PREDICTED: TBCC domain-containing protein 1-like [Glycine max] gi|356504841|ref|XP_003521203.1| | 12 | ||
| – | PREDICTED: tubulin-folding cofactor C-like [Cicer arietinum] gi|502140152|ref|XP_004504081.1| | 14 | ||
| – | Adenylyl cyclase-associated protein; TAIR: AT4G34490.1 cyclase associated protein 1; Swiss-Prot: sp|O65902|ACAP1_ARATH Cyclase-associated protein 1; TrEMBL-Plants: tr|I3T3J4|I3T3J4_LOTJA Adenylyl cyclase-associated protein; Found in the gene: LotjaGi1g1v0571000 | 21 | ||
| – | TBCC domain-containing protein 1; TAIR: AT3G57890.1 Tubulin binding cofactor C domain-containing protein; Swiss-Prot: sp|A1L0Z4|TBCC1_XENTR TBCC domain-containing protein 1; TrEMBL-Plants: tr|I1JNI6|I1JNI6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0724600 | 13 | ||
| – | Tubulin folding cofactor C, putative; TAIR: AT4G39920.1 C-CAP/cofactor C-like domain-containing protein; Swiss-Prot: sp|Q9SMR2|TBCC_ARATH Tubulin-folding cofactor C; TrEMBL-Plants: tr|A0A072TTR3|A0A072TTR3_MEDTR Tubulin folding cofactor C, putative; Found in the gene: LotjaGi4g1v0396500 | 15 | ||
| – | TBCC domain-containing protein 1; TAIR: AT3G57890.1 Tubulin binding cofactor C domain-containing protein; Swiss-Prot: sp|Q5ZKT1|TBCC1_CHICK TBCC domain-containing protein 1; TrEMBL-Plants: tr|I1JNI7|I1JNI7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0142700 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 12.50 |