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IPR002076 is a ELO family.
<p>The ELO family consist of eukaryotic integral membrane proteins involved in fatty acid elongation. This family consist of:</p> <ul> <li>Mammalian proteins ELOVL1 to ELOVL7 [[cite:PUB00018033], [cite:PUB00097862]]. These proteins catalyse the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle, each of them has a specific substrate specificity and physiological functions.</li> <li>Yeast ELO1, ELO2 and ELO3 [[cite:PUB00018034], [cite:PUB00097860]]. They are components of a microsomal membrane-bound long-chain fatty acid elongation system.</li> <li>Caenorhabditis elegans hypothetical protein C40H1.4.</li> <li>Caenorhabditis elegans hypothetical protein D2024.3.</li></ul> <p>This group of eukaryotic integral membrane proteins are evolutionary related and have from 290 to 435 amino acid residues. Structurally, they seem to be formed of three sections: a N-terminal region with two transmembrane domains, a central hydrophilic loop and a C-terminal region that contains from one to three transmembrane domains. Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis [[cite:PUB00002856]]. Yeast ELO3 ([swissprot:P40319]) affects plasma membrane H+-ATPase activity, and may act on a glucose-signalling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1 [[cite:PUB00002271]]. It plays an important role in lipotoxic cell death induced by oleic acid through maintaining a balanced fatty acid composition in the plasma membrane [[cite:PUB00097860]]. Mammalian ELOVLs are also associated with known pathologies. ELOVL1 catalyses elongation of saturated and monounsaturated C22-C26-VLCFAs, and dominant mutations cause ichthyosis, hypomyelination of the central white matter that leads to spastic paraplegia and central nystagmus and optic atrophy [[cite:PUB00097863]], dominant ELOVL4 mutations cause a juvenile macular dystrophy (Stargardt disease-3) and Elovl4 knockout mice die soon after birth due to a deficiency in skin barrier formation. Studies in Elovl6-null mice have revealed that ELOVL6 is involved in an obesity-induced insulin resistance and ELOVL7 is involved in prostate cancer growth [[cite:PUB00097862]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: elongation of fatty acids protein A-like [Cicer arietinum] gi|502153157|ref|XP_004509237.1| | 10 | ||
| – | PREDICTED: elongation of fatty acids protein A-like [Cicer arietinum] gi|502153157|ref|XP_004509237.1| | 12 | ||
| – | PREDICTED: elongation of fatty acids protein A-like [Glycine max] gi|356540732|ref|XP_003538839.1| | 8 | ||
| – | PREDICTED: elongation of fatty acids protein A-like [Cicer arietinum] gi|502131616|ref|XP_004501043.1| | 8 | ||
| – | PREDICTED: elongation of fatty acids protein A-like [Cicer arietinum] gi|502131616|ref|XP_004501043.1| | 8 | ||
| – | Elongation of fatty acids protein [Medicago truncatula] gi|357512049|ref|XP_003626313.1| | 10 | ||
| – | Elongation of fatty acids protein 3-like protein; TAIR: AT4G36830.1 GNS1/SUR4 membrane protein family; Swiss-Prot: sp|Q9SYY4|ELO3L_ARATH Elongation of fatty acids protein 3-like; TrEMBL-Plants: tr|A0A072V432|A0A072V432_MEDTR GNS1/SUR4 membrane family protein; Found in the gene: LotjaGi1g1v0417500 | 8 | ||
| – | Elongation of fatty acids protein 3-like; TAIR: AT4G36830.1 GNS1/SUR4 membrane protein family; Swiss-Prot: sp|Q9SYY4|ELO3L_ARATH Elongation of fatty acids protein 3-like; TrEMBL-Plants: tr|I1LHM3|I1LHM3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0394300 | 8 | ||
| – | Elongation of very long chain fatty acids protein 3; TAIR: AT3G06470.1 GNS1/SUR4 membrane protein family; Swiss-Prot: sp|Q9SYY4|ELO3L_ARATH Elongation of fatty acids protein 3-like; TrEMBL-Plants: tr|V7BR73|V7BR73_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0359100 | 10 | ||
| – | Elongation of very long chain fatty acids protein 3; TAIR: AT3G06470.1 GNS1/SUR4 membrane protein family; Swiss-Prot: sp|Q9SYY4|ELO3L_ARATH Elongation of fatty acids protein 3-like; TrEMBL-Plants: tr|A0A0L9VG63|A0A0L9VG63_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0359200 | 12 | ||
| – | Elongation of very long chain fatty acids protein 3; TAIR: AT3G06470.1 GNS1/SUR4 membrane protein family; Swiss-Prot: sp|Q9SYY4|ELO3L_ARATH Elongation of fatty acids protein 3-like; TrEMBL-Plants: tr|A0A0L9VG63|A0A0L9VG63_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0359200 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 9.09 |