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IPR002569 is a Peptide methionine sulphoxide reductase MsrA domain.
<p>Peptide methionine sulphoxide reductase (Msr) reverses the inactivation of many proteins due to the oxidation of critical methionine residues by reducing methionine sulphoxide, Met(O), to methionine [[cite:PUB00006537]]. It is present in most living organisms, and the cognate structural gene belongs to the so-called minimum gene set [[cite:PUB00015591], [cite:PUB00015592]].</p> <p>The domains MsrA and MsrB reduce different epimeric forms of methionine sulphoxide. This group represent MsrA, the crystal structure of which has been determined in a number of organisms. In Mycobacterium tuberculosis, the MsrA structure has been determined to 1.5 Angstrom resolution [[cite:PUB00015593]]. In contrast to the three catalytic cysteine residues found in previously characterised MsrA structures, M. tuberculosis MsrA represents a class containing only two functional cysteine residues. The overall structure shows no resemblance to the structures of MsrB ([interpro:IPR002579]) from other organisms; though the active sites show approximate mirror symmetry. In each case, conserved amino acid motifs mediate the stereo-specific recognition and reduction of the substrate.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Peptide-methionine (S)-S-oxide reductase activity | Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: peptide methionine sulfoxide reductase-like isoform X1 [Cicer arietinum] gi|502099125|ref|XP_004491395.1| | 8 | ||
| – | PREDICTED: peptide methionine sulfoxide reductase-like [Cicer arietinum] gi|502133645|ref|XP_004501840.1| | 10 | ||
| – | Peptide methionine sulfoxide reductase [Medicago truncatula] gi|357459589|ref|XP_003600075.1| | 10 | ||
| – | PREDICTED: peptide methionine sulfoxide reductase A5-like [Cicer arietinum] gi|502153469|ref|XP_004509351.1| | 16 | ||
| – | Peptide methionine sulfoxide reductase MsrA; TAIR: AT5G61640.2 peptidemethionine sulfoxide reductase 1; Swiss-Prot: sp|Q9SEC2|MSRA_LACSA Peptide methionine sulfoxide reductase; TrEMBL-Plants: tr|I1M6S0|I1M6S0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0029700 | 15 | ||
| – | Peptide methionine sulfoxide reductase MsrA; TAIR: AT5G61640.2 peptidemethionine sulfoxide reductase 1; Swiss-Prot: sp|Q9SEC2|MSRA_LACSA Peptide methionine sulfoxide reductase; TrEMBL-Plants: tr|I1M6R8|I1M6R8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0029700 | 16 | ||
| – | Peptide methionine sulfoxide reductase MsrA; TAIR: AT5G61640.1 peptidemethionine sulfoxide reductase 1; Swiss-Prot: sp|Q9SEC2|MSRA_LACSA Peptide methionine sulfoxide reductase; TrEMBL-Plants: tr|I1M6R8|I1M6R8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0030100_LC | 8 | ||
| – | Peptide methionine sulfoxide reductase MsrA; TAIR: AT5G61640.2 peptidemethionine sulfoxide reductase 1; Swiss-Prot: sp|P54152|MSRA_FRAAN Peptide methionine sulfoxide reductase; TrEMBL-Plants: tr|A0A067K443|A0A067K443_JATCU Uncharacterized protein; Found in the gene: LotjaGi1g1v0230600 | 10 | ||
| – | Peptide methionine sulfoxide reductase MsrA; TAIR: AT2G18030.1 Peptide methionine sulfoxide reductase family protein; Swiss-Prot: sp|Q9SL43|MSRA5_ARATH Peptide methionine sulfoxide reductase A5; TrEMBL-Plants: tr|I1JCI6|I1JCI6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0126800 | 16 | ||
| – | Peptide methionine sulfoxide reductase MsrA; TAIR: AT4G25130.1 peptide met sulfoxide reductase 4; Swiss-Prot: sp|Q9SEC2|MSRA_LACSA Peptide methionine sulfoxide reductase; TrEMBL-Plants: tr|I1JJ90|I1JJ90_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0160800 | 10 | ||
| – | Peptide methionine sulfoxide reductase MsrA; TAIR: AT4G25130.1 peptide met sulfoxide reductase 4; Swiss-Prot: sp|Q9SEC2|MSRA_LACSA Peptide methionine sulfoxide reductase; TrEMBL-Plants: tr|I1JJ90|I1JJ90_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0160800 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 9.09 |