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IPR028427 is a Peptide methionine sulfoxide reductase MsrB.
<p>The oxidation of methionine residues in proteins is considered to be one of the consequences of oxidative damage to cells, which in many cases leads to the loss of biological activity. Peptide methionine sulphoxide reductase (Msr) reverses the inactivation of many proteins due to the oxidation of critical methionine residues by reducing methionine sulphoxide, (MetO), to methionine [[cite:PUB00006537]]. Methionine (Met) can be oxidised to the R and S diastereomers of methionine sulfoxide (MetO). Methionine sulfoxide reductases A (MsrA) and B (MsrB) reduce MetO back to Met in a stereospecific manner, acting on the S and R forms, respectively. Msr is present in most living organisms [[cite:PUB00015591], [cite:PUB00015592]].</p> <p>Many bacteria, particularly pathogens, possess methionine sulfoxide reductase MsrA and MsrB as a fusion form (MsrAB) [[cite:PUB00083170]]. This entry includes MsrB and the fusion form of these enzymes.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Response to oxidative stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. | ||
| Molecular function | Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. | ||
| Biological process | Protein repair | The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: peptide methionine sulfoxide reductase-like isoform X1 [Cicer arietinum] gi|502099125|ref|XP_004491395.1| | 8 | ||
| – | PREDICTED: peptide methionine sulfoxide reductase-like [Cicer arietinum] gi|502133645|ref|XP_004501840.1| | 10 | ||
| – | Peptide methionine sulfoxide reductase [Medicago truncatula] gi|357459589|ref|XP_003600075.1| | 10 | ||
| – | PREDICTED: peptide methionine sulfoxide reductase B1, chloroplastic-like [Cicer arietinum] gi|502166101|ref|XP_004513790.1| | 10 | ||
| – | PREDICTED: peptide methionine sulfoxide reductase B2, chloroplastic-like [Cicer arietinum] gi|502142277|ref|XP_004504878.1| | 9 | ||
| – | PREDICTED: peptide methionine sulfoxide reductase A5-like [Cicer arietinum] gi|502153469|ref|XP_004509351.1| | 16 | ||
| – | PREDICTED: peptide methionine sulfoxide reductase B3, chloroplastic-like [Cicer arietinum] gi|502078905|ref|XP_004486092.1| | 9 | ||
| – | Peptide methionine sulfoxide reductase msrB; TAIR: AT1G53670.1 methionine sulfoxide reductase B 1; Swiss-Prot: sp|Q9C8M2|MSRB1_ARATH Peptide methionine sulfoxide reductase B1, chloroplastic; TrEMBL-Plants: tr|I3SVJ6|I3SVJ6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0038500 | 11 | ||
| – | Peptide methionine sulfoxide reductase msrB; TAIR: AT4G21860.1 methionine sulfoxide reductase B 2; Swiss-Prot: sp|Q9C5C8|MSRB2_ARATH Peptide methionine sulfoxide reductase B2, chloroplastic; TrEMBL-Plants: tr|I3T0F9|I3T0F9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0042500 | 10 | ||
| – | Peptide methionine sulfoxide reductase msrB; TAIR: AT4G21860.1 methionine sulfoxide reductase B 2; Swiss-Prot: sp|Q10L32|MSRB5_ORYSJ Peptide methionine sulfoxide reductase B5; TrEMBL-Plants: tr|A0A0L9VEM3|A0A0L9VEM3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0302700 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00357 | TIGRFAM | 1 | 10.00 |