Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR002842 is a V-type ATPase subunit E.
<p>Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP.</p> <p>The V-ATPases (or V1V0-ATPase) and A-ATPases (or A1A0-ATPase) are each composed of two linked complexes: the V1 or A1 complex contains the catalytic core that hydrolyses/synthesizes ATP, and the V0 or A0 complex that forms the membrane-spanning pore. The V-ATPase folding, localisation, and stability is made possible through the formation of a luminal glycan coat by the glycolipids and the glycosylated V0 subunits [[cite:PUB00099348]]. The V- and A-ATPases both contain rotary motors, one that drives proton translocation across the membrane and one that drives ATP synthesis/hydrolysis [[cite:PUB00009752], [cite:PUB00020609], [cite:PUB00020618]]. The V- and A-ATPases more closely resemble one another in subunit structure than they do the F-ATPases, although the function of A-ATPases is closer to that of F-ATPases.</p> <p>This entry represents subunit E from V-ATPases and A-ATPase/synthases. Subunit E appears to form a tight interaction with subunit G, which together may act as stators to prevent certain subunits from rotating with the central rotary element, much in the same way as the F0 complex subunit B does in F-ATPases [[cite:PUB00020636]]. In addition to its key role in stator structure, subunit E appears to have a role in mediating interactions with putative regulatory subunits [[cite:PUB00020637]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Proton-transporting two-sector ATPase complex, catalytic domain | A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. | ||
| Molecular function | Proton-transporting ATPase activity, rotational mechanism | Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. | ||
| Biological process | Proton transmembrane transport | The directed movement of a proton across a membrane. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: V-type proton ATPase subunit E [Vitis vinifera] gi|225426050|ref|XP_002274995.1| | 5 | ||
| – | PREDICTED: V-type proton ATPase subunit E-like [Cicer arietinum] gi|502139106|ref|XP_004503647.1| | 7 | ||
| – | V-type proton ATPase subunit E; TAIR: AT4G11150.1 vacuolar ATP synthase subunit E1; Swiss-Prot: sp|Q9SWE7|VATE_CITLI V-type proton ATPase subunit E; TrEMBL-Plants: tr|I3S5S1|I3S5S1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0437900 | 9 | ||
| – | V-type proton ATPase subunit E; TAIR: AT4G11150.1 vacuolar ATP synthase subunit E1; Swiss-Prot: sp|Q9SWE7|VATE_CITLI V-type proton ATPase subunit E; TrEMBL-Plants: tr|I3S5S1|I3S5S1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0437900 | 9 | ||
| – | V-type proton ATPase subunit E; TAIR: AT4G11150.1 vacuolar ATP synthase subunit E1; Swiss-Prot: sp|Q9SWE7|VATE_CITLI V-type proton ATPase subunit E; TrEMBL-Plants: tr|I3S5S1|I3S5S1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0437900 | 9 | ||
| – | V-type proton ATPase subunit E; TAIR: AT3G08560.1 vacuolar H+-ATPase subunit E isoform 2; Swiss-Prot: sp|Q9C9Z8|VATE2_ARATH V-type proton ATPase subunit E2; TrEMBL-Plants: tr|I1LJA5|I1LJA5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0511500 | 9 | ||
| – | V-type proton ATPase subunit E; TAIR: AT3G08560.1 vacuolar H+-ATPase subunit E isoform 2; Swiss-Prot: sp|Q9C9Z8|VATE2_ARATH V-type proton ATPase subunit E2; TrEMBL-Plants: tr|I1LJA5|I1LJA5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0511500 | 9 | ||
| – | V-type proton ATPase subunit E; TAIR: AT1G64200.1 vacuolar H+-ATPase subunit E isoform 3; Swiss-Prot: sp|Q9SWE7|VATE_CITLI V-type proton ATPase subunit E; TrEMBL-Plants: tr|I3S1Y2|I3S1Y2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0432500 | 9 | ||
| – | V-type proton ATPase subunit E; TAIR: AT1G64200.1 vacuolar H+-ATPase subunit E isoform 3; Swiss-Prot: sp|Q9SWE7|VATE_CITLI V-type proton ATPase subunit E; TrEMBL-Plants: tr|I3S1Y2|I3S1Y2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0432500 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF160527 | SUPERFAMILY | 1 | 11.11 |