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IPR002986 is a Diaminopimelate decarboxylase, LysA.
<p>Pyridoxal-dependent decarboxylases that act on ornithine-, lysine-, arginine- and related substrates can be classified into different families on the basis of sequence similarity [[cite:PUB00003632], [cite:PUB00001452]]. One of these families includes ornithine decarboxylase (ODC), which catalyses the transformation of ornithine into putrescine; prokaryotic diaminopimelate decarboxylase, which catalyses the conversion of diaminopimelate into lysine; Pseudomonas syringae pv. tabaci protein, tabA, which is probably involved in tabtoxin biosynthesis and is similar to diaminopimelate decarboxylase; and bacterial and plant biosynthetic arginine decarboxylase, which catalyses the transformation of arginine into agmatine, the first step in putrescine synthesis from arginine.</p> <p>Although these proteins, which are known collectively as group IV decarboxylases [[cite:PUB00001452]], probably share a common evolutionary origin, their levels of sequence similarity are low, being confined to a few short conserved regions. These conserved motifs suggest a common structural arrangement for positioning of substrate and the cofactor pyridoxal 5'-phosphate among bacterial diaminopimelate ddecarboxylases, eukaryotic ornithine decarboxylases and arginine decarboxylases [[cite:PUB00006113]].</p> <p>This entry represents the diaminopimelate decarboxylase LysA, which converts meso-diaminopimelate into lysine and is the last step of the DAP lysine biosynthetic pathway. The structure of bacterial diaminopimelate decarboxylase has been determined [[cite:PUB00014556]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Diaminopimelate decarboxylase activity | Catalysis of the reaction: meso-2,6-diaminopimelate + H(+) = L-lysine + CO(2). | ||
| Biological process | Lysine biosynthetic process via diaminopimelate | The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: diaminopimelate decarboxylase 1, chloroplastic-like [Cicer arietinum] gi|502161433|ref|XP_004512163.1| | 23 | ||
| – | PREDICTED: diaminopimelate decarboxylase 1, chloroplastic-like [Cicer arietinum] gi|502161433|ref|XP_004512163.1| | 22 | ||
| – | Diaminopimelate decarboxylase; TAIR: AT5G11880.1 Pyridoxal-dependent decarboxylase family protein; Swiss-Prot: sp|Q94A94|DCDA2_ARATH Diaminopimelate decarboxylase 2, chloroplastic; TrEMBL-Plants: tr|A0A151TUY1|A0A151TUY1_CAJCA Uncharacterized protein; Found in the gene: LotjaGi1g1v0690900 | 23 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd06828 | CDD | 1 | 33.33 |