Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR003309 is a SCAN domain.
<p>A number of C2H2-zinc finger proteins contain a highly conserved N-terminal motif termed the SCAN (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) domain. The SCAN domain has been shown to be able to mediate homo- and hetero-oligomerisation [[cite:PUB00008090]]. These proteins can either activate or repress transcription, although isolated recombinant SCAN domains do not modulate significantly the transcription [[cite:PUB00018272], [cite:PUB00018273]]. In addition to these zinc finger transcription factors, an isolated SCAN domain without adjacent zinc finger motifs has been identified in some proteins [[cite:PUB00018274], [cite:PUB00018275]]. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein [[cite:PUB00032595]].</p> <p>The SCAN domain is enriched in hydrophobic and negatively charged residues with a L-X(6)-L motif at its core. This core is flanked by A, E, L, M, H and C residues that are frequently found in α-helices [[cite:PUB00018273]]. Predictions of the secondary structure of the domain suggest the presence of at least three α-helices that are separated from one another by short looped regions bounded by proline residues [[cite:PUB00008090]]. It has been shown to be a selective oligomerization domain that mediates homotypic and heterotypic interactions between SCAN box containing proteins [[cite:PUB00018275], [cite:PUB00008090]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA-binding transcription factor activity | A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. | ||
| Biological process | Regulation of transcription, DNA-templated | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: coiled-coil domain-containing protein 132-like [Glycine max] gi|356542692|ref|XP_003539800.1| | 9 | ||
| – | PREDICTED: coiled-coil domain-containing protein 132-like [Glycine max] gi|356542692|ref|XP_003539800.1| | 9 | ||
| – | PREDICTED: coiled-coil domain-containing protein 132-like [Glycine max] gi|356542692|ref|XP_003539800.1| | 9 | ||
| – | Coiled-coil domain-containing protein 132; TAIR: AT2G27900.1 coiled-coil protein; Swiss-Prot: sp|Q5ZKV9|VPS50_CHICK Syndetin; TrEMBL-Plants: tr|I1LRA9|I1LRA9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0482400 | 10 | ||
| – | Coiled-coil domain-containing protein 132; TAIR: AT2G27900.1 coiled-coil protein; Swiss-Prot: sp|Q5ZKV9|VPS50_CHICK Syndetin; TrEMBL-Plants: tr|I1LRA9|I1LRA9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0482400 | 15 | ||
| – | Coiled-coil domain-containing protein 132; TAIR: AT2G27900.1 coiled-coil protein; Swiss-Prot: sp|Q5ZKV9|VPS50_CHICK Syndetin; TrEMBL-Plants: tr|I1LRA9|I1LRA9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0482400 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 16.67 |