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IPR003521 is a ICln.
<p>ICln, known as methylosome subunit pICln or chloride conductance regulatory protein ICln, owes these different names to its function in multiple regulatory pathways [[cite:PUB00070162]] as different as ion permeation, ribonucleoprotein biosynthesis and cytoskeletal organisation [[cite:PUB00070163]]. ICln can be identified both in the cytosol and in the cellular membrane, where it functions as a chloride current regulator and is important in regulating volume decrease after cellular swelling [[cite:PUB00070164], [cite:PUB00070165], [cite:PUB00070166], [cite:PUB00070167]].</p> <p>pLCln also functions as a Sm chaperone in the stepwise snRNP assembly process [[cite:PUB00069474]]. snRNPs is a RNA-protein complex esessential to the removal of introns from pre-mRNA [[cite:PUB00069473], [cite:PUB00066801]]. In humans, the core of snRNPs is composed of seven Sm proteins bound to snRNA. pLCln tethers the hetero-oligomers SmD1/D2 and SmE/F/G into a ring-shaped 6S complex, which subsequently docks onto the SMN complex. The SMN complex then removes pICln and enables the transfer of pre-assembled Sm proteins onto snRNA [[cite:PUB00065020]]. Consistent with the role of human pICln, the orthologue from S. pombe is required for optimal production of the spliceosomal snRNPs and for efficient splicing [[cite:PUB00069468]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Spliceosomal snRNP assembly | The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. | ||
| Cellular component | Cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. | ||
| Cellular component | Plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. | ||
| Biological process | Chloride transport | The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | ||
| Biological process | Cell volume homeostasis | Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell. | ||
| Cellular component | Methylosome | A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains. | ||
| Cellular component | PICln-Sm protein complex | A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Chloride conductance regulatory protein ICln protein; TAIR: AT5G62290.2 nucleotide-sensitive chloride conductance regulator (ICln) family protein; Swiss-Prot: sp|Q9LVA7|ICLN_ARATH Chloride conductance regulatory protein ICln; TrEMBL-Plants: tr|I3T898|I3T898_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0554700 | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF50729 | SUPERFAMILY | 1 | 100.00 |