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IPR003749 is a Sulfur carrier ThiS/MoaD-like.
<p>ThiS (thiaminS) is a 66 aa protein involved in sulphur transfer. ThiS is coded in the thiCEFSGH operon in Escherichia coli. This family of proteins have two conserved Glycines at the COOH terminus. Thiocarboxylate is formed at the last G in the activation process. Sulphur is transferred from ThiI to ThiS in a reaction catalysed by IscS [[cite:PUB00007564]]. MoaD, a protein involved in sulphur transfer during molybdopterin synthesis, is about the same length and shows limited sequence similarity to ThiS. Both have the conserved GG at the COOH end [[cite:PUB00035630]].</p> <p>ThiS/MoaD proteins serve as sulfur carriers in thiamine and tungsten/molybdenum cofactor biosynthesis. Proteins in this entry also include TtuB from Thermus thermophilus. TtuB functions as the sulfur donor in the sulfurtransferase reaction catalyzed by TtuA [[cite:PUB00088041]]. It is also required for the 2-thiolation of 5-methyluridine residue at position 54 in the T loop of tRNAs, leading to 5-methyl-2-thiouridine (m5s2U or s2T). This modification allows thermal stabilization of tRNAs in thermophilic microorganisms, and is essential for cell growth at high temperatures [[cite:PUB00088042]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Molybdopterin synthase sulfur carrier subunit [Medicago truncatula] gi|357455873|ref|XP_003598217.1| | 13 | ||
| – | PREDICTED: molybdopterin synthase sulfur carrier subunit-like [Cicer arietinum] gi|502127319|ref|XP_004499653.1| | 13 | ||
| – | Molybdopterin synthase sulfur carrier subunit; TAIR: AT4G10100.1 co-factor for nitrate, reductase and xanthine dehydrogenase 7; Swiss-Prot: sp|Q9S7A3|MOC2A_ARATH Molybdopterin synthase sulfur carrier subunit; TrEMBL-Plants: tr|I3T2W6|I3T2W6_LOTJA Molybdopterin synthase sulfur carrier subunit; Found in the gene: LotjaGi3g1v0328000 | 11 | ||
| – | Molybdopterin synthase sulfur carrier subunit; TAIR: AT4G10100.1 co-factor for nitrate, reductase and xanthine dehydrogenase 7; Swiss-Prot: sp|Q9S7A3|MOC2A_ARATH Molybdopterin synthase sulfur carrier subunit; TrEMBL-Plants: tr|I3T2W6|I3T2W6_LOTJA Molybdopterin synthase sulfur carrier subunit; Found in the gene: LotjaGi3g1v0328000 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00754 | CDD | 1 | 25.00 |