Description

IPR029030 is a Caspase-like domain superfamily.

<p>This superfamily represents the caspase-like domain found in caspases, metacaspases and peptidases of the C25 family (gingipains).</p> <p>Caspases (Cysteine-dependent ASPartyl-specific proteASE) are cysteine peptidases [[cite:PUB00011704]]. They are tightly regulated proteins that require zymogen activation to become active, and once active can be regulated by caspase inhibitors. Caspases are mainly involved in mediating cell death (apoptosis) [[cite:PUB00015006], [cite:PUB00015008], [cite:PUB00014747]]. They have two main roles within the apoptosis cascade: as initiators that trigger the cell death process, and as effectors of the process itself. Caspases can have roles other than in apoptosis, such as caspase-1 (interleukin-1 beta convertase) ([ec:3.4.22.36]), which is involved in the inflammatory process. The activation of apoptosis can sometimes lead to caspase-1 activation, providing a link between apoptosis and inflammation, such as during the targeting of infected cells. Caspases may also be involved in cell differentiation [[cite:PUB00014748]].</p> <p>Metacaspases are arginine/lysine-specific, in contrast to caspases, which are aspartate-specific. They are found only in plants [[cite:PUB00066783], [cite:PUB00066782]], fungi [[cite:PUB00066784]] and lower eukaryotes, including the protozoa [[cite:PUB00066785]]. While plant metacaspases have been shown to be involved in cell death pathways, in other organisms they have evolved alternative functions [[cite:PUB00066787]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 29

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: