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IPR004113 is a FAD-binding oxidoreductase/transferase, type 4, C-terminal.
<p>This entry represents a domain found in a group of type 4 FAD-binding oxidoreductase/transferases and similar proteins from all cellular organisms, including D-2-hydroxyglutarate dehydrogenase from humans [[cite:PUB00103960]] and Escherichia coli [[cite:PUB00103958]], Alkyldihydroxyacetonephosphate synthase from Caenorhabditis elegans and D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2 from Saccharomyces cerevisiae [[cite:PUB00103959]]. This domain, often found at the C-terminal end of the proteins, shows a ferredoxin-like fold [[cite:PUB00019533]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Catalytic activity | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. | ||
| Molecular function | Flavin adenine dinucleotide binding | Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: D-lactate dehydrogenase [cytochrome] gi|356505459|ref|XP_003521508.1| | 17 | ||
| – | PREDICTED: d-2-hydroxyglutarate dehydrogenase, mitochondrial-like [Cicer arietinum] gi|502161240|ref|XP_004512090.1| | 17 | ||
| – | D-lactate dehydrogenase, putative; TAIR: AT5G06580.1 FAD-linked oxidases family protein; Swiss-Prot: sp|Q94AX4|DLD_ARATH D-lactate dehydrogenase [cytochrome], mitochondrial; TrEMBL-Plants: tr|I1JQD0|I1JQD0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0741700 | 20 | ||
| – | D-lactate dehydrogenase, putative; TAIR: AT5G06580.1 FAD-linked oxidases family protein; Swiss-Prot: sp|Q94AX4|DLD_ARATH D-lactate dehydrogenase [cytochrome], mitochondrial; TrEMBL-Plants: tr|A0A072U583|A0A072U583_MEDTR D-lactate dehydrogenase (Cytochrome); Found in the gene: LotjaGi1g1v0741700 | 9 | ||
| – | D-2-hydroxyglutarate dehydrogenase, mitochondrial; TAIR: AT4G36400.1 FAD-linked oxidases family protein; Swiss-Prot: sp|O23240|D2HDH_ARATH D-2-hydroxyglutarate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|G7KGB4|G7KGB4_MEDTR D-2-hydroxyglutarate dehydrogenase; Found in the gene: LotjaGi2g1v0385200 | 20 | ||
| – | D-2-hydroxyglutarate dehydrogenase, mitochondrial; TAIR: AT4G36400.1 FAD-linked oxidases family protein; Swiss-Prot: sp|O23240|D2HDH_ARATH D-2-hydroxyglutarate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A0R0HMH0|A0A0R0HMH0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0385200 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF56176 | SUPERFAMILY | 1 | 16.67 |