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IPR004162 is a E3 ubiquitin-protein ligase SINA-like, animal.
<p>Proteins in this entry are E3 ubiquitin-protein ligases that mediate ubiquitination and subsequent proteasomal degradation of target proteins. Proteins in this entry include Sina and Sinah (Sina homologue) from flies and SIAH1/2 from humans.</p> <p>The seven in absentia (sina) gene was first identified in Drosophila. The Drosophila Sina protein is essential for the determination of the R7 pathway in photoreceptor cell development: the loss of functional Sina results in the transformation of the R7 precursor cell to a non-neuronal cell type. The Sina protein contains an N-terminal RING finger domain C3HC4-type. Through this domain, Sina binds E2 ubiquitin-conjugating enzymes (UbcD1). Sina also interacts with Tramtrack (TTK88) via PHYL. Tramtrack is a transcriptional repressor that blocks photoreceptor determination, while PHYL down-regulates the activity of TTK88. In turn, the activity of PHYL requires the activation of the Sevenless receptor tyrosine kinase, a process essential for R7 determination. It is thought that Sina targets TTK88 for degradation, therefore promoting the R7 pathway. Murine and human homologues of Sina have also been identified. The human homologue SIAH1 [[cite:PUB00007400]] also binds E2 enzymes (UbcH5) and through a series of physical interactions, targets beta-catenin for ubiquitin degradation. Siah-1 expression is enhanced by p53, itself promoted by DNA damage. Thus this pathway links DNA damage to beta-catenin degradation [[cite:PUB00007401], [cite:PUB00007402]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. | ||
| Biological process | Multicellular organism development | The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). | ||
| Cellular component | Host cell nucleus | A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | E3 ubiquitin ligase-like protein, partial [Lotus japonicus] gi|379055947|emb|CCG06555.1| | 16 | ||
| – | E3 ubiquitin ligase-like protein [Lotus japonicus] gi|379055943|emb|CCG06553.1| | 9 | ||
| – | PREDICTED: E3 ubiquitin-protein ligase SINAT3-like [Cicer arietinum] gi|502156841|ref|XP_004510666.1| | 18 | ||
| – | PREDICTED: E3 ubiquitin-protein ligase SINAT3-like [Glycine max] gi|356573229|ref|XP_003554765.1| | 18 | ||
| – | E3 ubiquitin ligase-like protein, partial [Lotus japonicus] gi|379055947|emb|CCG06555.1| | 17 | ||
| – | E3 ubiquitin ligase-like protein, partial [Lotus japonicus] gi|379055947|emb|CCG06555.1| | 12 | ||
| – | PREDICTED: E3 ubiquitin-protein ligase SINAT5-like [Cicer arietinum] gi|502183151|ref|XP_004517074.1| | 13 | ||
| – | E3 ubiquitin ligase [Lotus japonicus] gi|379055945|emb|CCG06554.1| | 20 | ||
| – | E3 ubiquitin ligase-like protein [Lotus japonicus] gi|379055941|emb|CCG06552.1| | 18 | ||
| – | E3 ubiquitin ligase [Lotus japonicus] gi|379055939|emb|CCG06551.1| | 19 | ||
| – | PREDICTED: E3 ubiquitin-protein ligase SINA-like 10-like [Cicer arietinum] gi|502141970|ref|XP_004504728.1| | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 9.09 |