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IPR004368

Source: InterPro

Description

IPR004368 is a Translation initiation factor IF-1.

<p>This family consists of translation initiation factor IF-1 as found in bacteria and chloroplasts. This protein, about 70 residues in length, consists largely of an S1 RNA binding domain ([interpro:IPR003029]) [[cite:PUB00000944]]. <p>Translation initiation includes a number of interrelated steps preceding the formation of the first peptide bond. In Escherichia coli, the initiation mechanism requires, in addition to mRNA, fMet-tRNA, and ribosomal subunits, the presence of three additional proteins (initiation factors IF1, IF2, and IF3) and at least one GTP molecule. The three initiation factors influence both the kinetics and the stability of ternary complex formation. IF1 is the smallest of the three factors. IF1 enhances the rate of 70S ribosome subunit association and dissociation and the interaction of 30S ribosomal subunit with IF2 and IF3. It stimulates 30S complex formation. In addition, by binding to the A-site of the 30S ribosomal subunit, IF1 may contribute to the fidelity of the selection of the initiation site of the mRNA [[cite:PUB00028173], [cite:PUB00081032], [cite:PUB00025767], [cite:PUB00081033], [cite:PUB00081034]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003743
Molecular function Translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
Subterm of
GO:0006413
Biological process Translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
Subterm of
Part of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj0g3v0326949.1
– Translation initiation factor [Medicago truncatula] gi|357516503|ref|XP_003628540.1|
Domains
14
LotjaGi3g1v0047700.1
– Translation initiation factor IF-1; TAIR: AT4G11175.1 Nucleic acid-binding, OB-fold-like protein; Swiss-Prot: sp|Q94KR7|IF1C_SOYBN Translation initiation factor IF-1, chloroplastic; TrEMBL-Plants: tr|G7LDQ8|G7LDQ8_MEDTR Translation initiation factor IF-1; Found in the gene: LotjaGi3g1v0047700
Domains
14

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd04451 CDD 1 50.00