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IPR006196 is a RNA-binding domain, S1, IF1 type.
<p>The S1 domain of around 70 amino acids, originally identified in ribosomal protein S1, is found in a large number of RNA-associated proteins. It has been shown that S1 proteins bind RNA through their S1 domains with some degree of sequence specificity. This type of S1 domain is found in translation initiation factor 1.</p> <p>The solution structure of one S1 RNA-binding domain from Escherichia coli polynucleotide phosphorylase has been determined [[cite:PUB00000944]]. It displays some similarity with the cold shock domain (CSD) ([interpro:IPR002059]). Both the S1 and the CSD domain consist of an antiparallel β barrel of the same topology with 5 β strands. This fold is also shared by many other proteins of unrelated function and is known as the OB fold. However, the S1 and CSD fold can be distinguished from the other OB folds by the presence of a short 3(10) helix at the end of strand 3. This unique feature is likely to form a part of the DNA/RNA-binding site.</p> <p>This entry is specific for bacterial, chloroplastic and eukaryotic IF-1 type S1 domains.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. | ||
| Molecular function | Translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. | ||
| Biological process | Translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Translation initiation factor [Medicago truncatula] gi|357516503|ref|XP_003628540.1| | 14 | ||
| – | PREDICTED: probable RNA-binding protein EIF1AD-like [Cicer arietinum] gi|502163627|ref|XP_004512897.1| | 9 | ||
| – | PREDICTED: probable RNA-binding protein EIF1AD-like [Cicer arietinum] gi|502163627|ref|XP_004512897.1| | 9 | ||
| – | PREDICTED: eukaryotic translation initiation factor 1A-like [Cicer arietinum] gi|502084002|ref|XP_004487629.1| | 13 | ||
| – | PREDICTED: eukaryotic translation initiation factor 1A-like [Cicer arietinum] gi|502084002|ref|XP_004487629.1| | 14 | ||
| – | Eukaryotic translation initiation factor 1A; TAIR: AT2G40780.1 Nucleic acid-binding, OB-fold-like protein; Swiss-Prot: sp|Q58CY2|EIF1A_BOVIN Probable RNA-binding protein EIF1AD; TrEMBL-Plants: tr|A0A0L9UEA0|A0A0L9UEA0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0305200 | 11 | ||
| – | Eukaryotic translation initiation factor 1A; TAIR: AT2G40780.1 Nucleic acid-binding, OB-fold-like protein; Swiss-Prot: sp|Q58CY2|EIF1A_BOVIN Probable RNA-binding protein EIF1AD; TrEMBL-Plants: tr|A0A0L9UEA0|A0A0L9UEA0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0305200 | 11 | ||
| – | Eukaryotic translation initiation factor 1A; TAIR: AT2G04520.1 Nucleic acid-binding, OB-fold-like protein; Swiss-Prot: sp|P56331|IF1A_ONOVI Eukaryotic translation initiation factor 1A; TrEMBL-Plants: tr|I3SHT8|I3SHT8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0392400 | 16 | ||
| – | Translation initiation factor IF-1; TAIR: AT4G11175.1 Nucleic acid-binding, OB-fold-like protein; Swiss-Prot: sp|Q94KR7|IF1C_SOYBN Translation initiation factor IF-1, chloroplastic; TrEMBL-Plants: tr|G7LDQ8|G7LDQ8_MEDTR Translation initiation factor IF-1; Found in the gene: LotjaGi3g1v0047700 | 14 | ||
| – | Eukaryotic translation initiation factor 1A; TAIR: AT2G04520.1 Nucleic acid-binding, OB-fold-like protein; Swiss-Prot: sp|P56331|IF1A_ONOVI Eukaryotic translation initiation factor 1A; TrEMBL-Plants: tr|I3T689|I3T689_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0390300 | 16 | ||
| – | Eukaryotic translation initiation factor 1A; TAIR: AT2G40780.1 Nucleic acid-binding, OB-fold-like protein; Swiss-Prot: sp|Q3THJ3|EIF1A_MOUSE Probable RNA-binding protein EIF1AD; TrEMBL-Plants: tr|V7AS60|V7AS60_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0337600 | 11 | ||
| – | Eukaryotic translation initiation factor 1A; TAIR: AT2G40780.1 Nucleic acid-binding, OB-fold-like protein; Swiss-Prot: sp|Q3THJ3|EIF1A_MOUSE Probable RNA-binding protein EIF1AD; TrEMBL-Plants: tr|V7AS60|V7AS60_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0337600 | 11 | ||
| – | Eukaryotic translation initiation factor 1A; TAIR: AT2G40780.1 Nucleic acid-binding, OB-fold-like protein; Swiss-Prot: sp|Q3THJ3|EIF1A_MOUSE Probable RNA-binding protein EIF1AD; TrEMBL-Plants: tr|V7AS60|V7AS60_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0337600 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 7.69 |