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IPR004373 is a Peptide chain release factor 1.
<p>This entry represents peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognise and terminate translation at UAA and UAG stop codons [[cite:PUB00085732]]. This entry also includes chloroplast release factor APG3, which is an orthologue of E. coli RF1 and is essential for chloroplast development. APG3 could complement E. coli RF1 mutants, but not RF2 mutants, indicating that AP3 may function as RF1 in E. coli, showing specificity of stop codon recognition [[cite:PUB00085731]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Translational termination | The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). | ||
| Molecular function | Translation release factor activity, codon specific | A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: peptide chain release factor 1-like [Glycine max] gi|356503962|ref|XP_003520768.1| | 14 | ||
| – | PREDICTED: peptide chain release factor 1-like [Glycine max] gi|356505530|ref|XP_003521543.1| | 15 | ||
| – | Peptide chain release factor 1; TAIR: AT2G47020.1 Peptide chain release factor 1; Swiss-Prot: sp|A5V9C3|RF1_SPHWW Peptide chain release factor 1; TrEMBL-Plants: tr|K7KGG4|K7KGG4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0754900 | 14 | ||
| – | Peptide chain release factor 1; TAIR: AT3G62910.1 Peptide chain release factor 1; Swiss-Prot: sp|Q8RX79|APG3_ARATH Peptide chain release factor APG3, chloroplastic; TrEMBL-Plants: tr|I1JQI6|I1JQI6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0768000 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00019 | TIGRFAM | 1 | 25.00 |