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IPR004487 is a Clp protease, ATP-binding subunit ClpX.
<p>ClpX is a member of the HSP (heat-shock protein) 100 family. Gel filtration and electron microscopy showed that ClpX subunits associate to form a six-membered ring that is stabilised by binding of ATP or nonhydrolysable analogs of ATP [[cite:PUB00015582]]. It functions as an ATP-dependent [[cite:PUB00015582]] molecular chaperone and is the regulatory subunit of the ClpXP protease [[cite:PUB00011891]].</p> <p>ClpXP is involved in DNA damage repair, stationary-phase gene expression, and ssrA-mediated protein quality control. To date more than 50 proteins include transcription factors, metabolic enzymes, and proteins involved in the starvation and oxidative stress responses have been identified as substrates [[cite:PUB00011892]].</p> <p>The N-terminal domain of ClpX is a C4-type zinc binding domain (ZBD) involved in substrate recognition. ZBD forms a very stable dimer that is essential for promoting the degradation of some typical ClpXP substrates such as lO and MuA [[cite:PUB00011897]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | Protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. | ||
| Molecular function | Unfolded protein binding | Interacting selectively and non-covalently with an unfolded protein. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ATP-dependent Clp protease ATP-binding subunit ClpX-like [Fragaria vesca subsp]. vesca] gi|470128173|ref|XP_004300022.1| | 22 | ||
| – | PREDICTED: ATP-dependent Clp protease ATP-binding subunit ClpX-like [Cicer arietinum] gi|502162893|ref|XP_004512653.1| | 24 | ||
| – | PREDICTED: ATP-dependent Clp protease ATP-binding subunit ClpX-like isoform X1 [Cicer arietinum] gi|502136340|ref|XP_004502651.1| | 12 | ||
| – | ATP-dependent Clp protease ATP-binding subunit clpX; TAIR: AT5G53350.1 CLP protease regulatory subunit X; Swiss-Prot: sp|Q9FK07|CLPX1_ARATH CLP protease regulatory subunit CLPX1, mitochondrial; TrEMBL-Plants: tr|A0A0S3RDV9|A0A0S3RDV9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0286700 | 17 | ||
| – | ATP-dependent Clp protease ATP-binding subunit ClpX; TAIR: AT1G33360.1 ATP-dependent Clp protease; Swiss-Prot: sp|Q66GN9|CLPX3_ARATH CLP protease regulatory subunit CLPX3, mitochondrial; TrEMBL-Plants: tr|I1MQ99|I1MQ99_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0162800 | 16 | ||
| – | ATP-dependent Clp protease ATP-binding subunit ClpX; TAIR: AT1G33360.1 ATP-dependent Clp protease; Swiss-Prot: sp|Q66GN9|CLPX3_ARATH CLP protease regulatory subunit CLPX3, mitochondrial; TrEMBL-Plants: tr|I1MQ99|I1MQ99_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0162800 | 24 | ||
| – | ATP-dependent Clp protease ATP-binding subunit ClpX; TAIR: AT5G49840.2 ATP-dependent Clp protease; Swiss-Prot: sp|F4K7F6|CLPX2_ARATH CLP protease regulatory subunit CLPX2, mitochondrial; TrEMBL-Plants: tr|A0A061GFF2|A0A061GFF2_THECC ATP-dependent Clp protease isoform 2; Found in the gene: LotjaGi4g1v0001900 | 22 | ||
| – | ATP-dependent Clp protease ATP-binding subunit ClpX; TAIR: AT5G53350.1 CLP protease regulatory subunit X; Swiss-Prot: sp|Q9FK07|CLPX1_ARATH CLP protease regulatory subunit CLPX1, mitochondrial; TrEMBL-Plants: tr|A0A1J7G8K0|A0A1J7G8K0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0195500 | 17 | ||
| – | ATP-dependent Clp protease ATP-binding subunit clpX; TAIR: AT5G53350.1 CLP protease regulatory subunit X; Swiss-Prot: sp|Q9FK07|CLPX1_ARATH CLP protease regulatory subunit CLPX1, mitochondrial; TrEMBL-Plants: tr|I3SQF7|I3SQF7_LOTJA Pectinesterase; Found in the gene: LotjaGi6g1v0123900_LC | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF52540 | SUPERFAMILY | 1 | 11.11 |