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IPR004504 is a DNA repair protein RadA.
<p>RadA/Sms is a highly conserved eubacterial protein that shares sequence similarity with both RecA strand transferase and lon protease. The RadA/Sms family are ATP-dependent proteases involved in both DNA repair and degradation of proteins, peptides, glycopeptides. They are classified in MEROPS peptidase family S16 (lon protease family, clan SJ).</p> <p>RadA/Sms is involved in recombination and recombinational repair, most likely involving the stabilisation or processing of branched DNA molecules or blocked replication forks [[cite:PUB00011878], [cite:PUB00100747]] and in the integration of exogenous DNA into the genome during bacterial genetic transformation [[cite:PUB00106485]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Damaged DNA binding | Interacting selectively and non-covalently with damaged DNA. | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA repair protein RadA homolog [Cicer arietinum] gi|502081182|ref|XP_004486791.1| | 19 | ||
| – | DNA repair protein radA-like protein [Medicago truncatula] gi|357513543|ref|XP_003627060.1| | 19 | ||
| – | DNA repair protein RadA like; TAIR: AT5G50340.1 DNA repair protein RadA-like protein; Swiss-Prot: sp|P37572|RADA_BACSU DNA repair protein RadA; TrEMBL-Plants: tr|G7IHX8|G7IHX8_MEDTR DNA repair-like proteinRadA; Found in the gene: LotjaGi3g1v0022200 | 19 | ||
| – | DNA repair protein RadA like; TAIR: AT5G50340.1 DNA repair protein RadA-like protein; Swiss-Prot: sp|Q92F42|RADA_LISIN DNA repair protein RadA; TrEMBL-Plants: tr|G7LGQ6|G7LGQ6_MEDTR DNA repair-like proteinRadA; Found in the gene: LotjaGi3g1v0372600 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |