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IPR004524 is a Aspartate-tRNA ligase, type 1.
<p>Aspartate tRNA ligase (also known as Aspartyl-tRNA synthetase, AspRS) [ec:6.1.1.12] is an alpha2 dimer that belongs to class IIb. Structural analysis combined with mutagenesis and enzymology data on the yeast enzyme point to a tRNA binding process that starts by a recognition event between the tRNA anticodon loop and the ligase anticodon binding module [[cite:PUB00006538]]. In some species, this enzyme aminoacylates tRNA for both Asp and Asn; Asp-tRNA(asn) is subsequently transamidated to Asn-tRNA(asn).</p> <p>This family represents aspartate-tRNA ligases from mostly bacteria and eukaryotic mitochondria.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Molecular function | Ligase activity | Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: aspartate--tRNA ligase-like isoform X1 [Cicer arietinum] gi|502138374|ref|XP_004503382.1| | 31 | ||
| – | PREDICTED: aspartate--tRNA ligase-like isoform X1 [Cicer arietinum] gi|502138374|ref|XP_004503382.1| | 14 | ||
| – | Aspartate--tRNA ligase; TAIR: AT4G33760.1 tRNA synthetase class II (D, K and N) family protein; Swiss-Prot: sp|F4JJT9|SYDM_ARATH Aspartate--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A151T3C0|A0A151T3C0_CAJCA Aspartyl-tRNA synthetase; Found in the gene: LotjaGi4g1v0454600 | 30 | ||
| – | Aspartate--tRNA ligase; TAIR: AT4G33760.1 tRNA synthetase class II (D, K and N) family protein; Swiss-Prot: sp|F4JJT9|SYDM_ARATH Aspartate--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A151T3C0|A0A151T3C0_CAJCA Aspartyl-tRNA synthetase; Found in the gene: LotjaGi4g1v0454600 | 28 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04317 | CDD | 1 | 25.00 |