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IPR004574 is a Alkylated DNA repair protein AlkB.
<p>AlkB proteins are dioxygenases that repair alkylation damage to DNA and RNA [[cite:PUB00076916]]. The Escherichia coli alkB gene product protects against cell killing by S(N)2-alkylating agents through DNA repair by a novel direct reversal DNA repair mechanism: the oxidative demethylation of N1-methyladenine or N3-methylcytosine DNA lesions. This reaction occurs on both single- and double-stranded DNA, and requires AlkB-bound non-heme Fe(2+), O(2) and alpha-ketogluterate to oxidize the offending methyl group. This is followed by the release of succinate, CO(2) and formaldehyde, and the restoration of undamaged A or C in DNA [[cite:PUB00010126]].</p> <p>Nine mammalian AlkB homologues exist (ALKBH1-8, FTO), but only a subset functions as DNA/RNA repair enzymes [[cite:PUB00076917]], and only ALKBH1 is included in this entry. In humans, ALKBH1 (ABH1) is responsible for the conversion of 5-methylcytosine to 5-formylcytosine (f5C) in position 34 in mitochondrial tRNAMet [[cite:PUB00088328]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: alpha-ketoglutarate-dependent dioxygenase AlkB homolog [Glycine max] gi|356573293|ref|XP_003554797.1| | 10 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase alkB-like protein [Medicago truncatula] gi|357470119|ref|XP_003605344.1| | 15 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase alkB-like protein [Medicago truncatula] gi|357470119|ref|XP_003605344.1| | 13 | ||
| – | Alkylated DNA repair protein alkB-like protein [Medicago truncatula] gi|357462995|ref|XP_003601779.1| | 9 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase AlkB like; TAIR: AT3G14160.1 2-oxoglutarate-dependent dioxygenase family protein; Swiss-Prot: sp|P05050|ALKB_ECOLI Alpha-ketoglutarate-dependent dioxygenase AlkB; TrEMBL-Plants: tr|A0A0L9TEQ1|A0A0L9TEQ1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0799900 | 11 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase AlkB; TAIR: AT5G01780.2 2-oxoglutarate-dependent dioxygenase family protein; Swiss-Prot: sp|P05050|ALKB_ECOLI Alpha-ketoglutarate-dependent dioxygenase AlkB; TrEMBL-Plants: tr|A0A1J7IJV0|A0A1J7IJV0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0203300 | 16 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase AlkB; TAIR: AT5G01780.5 2-oxoglutarate-dependent dioxygenase family protein; Swiss-Prot: sp|Q5EAC5|ZN410_BOVIN Zinc finger protein 410; TrEMBL-Plants: tr|A0A1J7IJV0|A0A1J7IJV0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0203300 | 14 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase alkB; TAIR: AT1G11780.1 oxidoreductase, 2OG-Fe(II) oxygenase family protein; Swiss-Prot: sp|Q9SA98|ALKBH_ARATH Alpha-ketoglutarate-dependent dioxygenase alkB; TrEMBL-Plants: tr|I3T319|I3T319_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0097800 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF51197 | SUPERFAMILY | 1 | 12.50 |