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IPR037151 is a Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily.
<p>This superfamily brings together catalytic domains found in Alpha-ketoglutarate-dependent dioxygenase AlkB-like DNA/RNA demethylases.</p> <p>AlkB is a DNA repair enzyme that removes methyl adducts and some larger alkylation lesions from endocyclic positions on purine and pyrimidine bases. It is a dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron [[cite:PUB00064960], [cite:PUB00064961]].</p> <p>The catalytic core of AlkB is homologous to other Fe-2OG dioxygenases [[cite:PUB00064580], [cite:PUB00076935]]. Two discrete global conformations have been observed for AlkB, differing in accessibility of a putative oxygen-diffusion tunnel [[cite:PUB00053097]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | RNA-binding (RRM/RBD/RNP motifs) family protein; TAIR: AT4G02485.1 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein; Swiss-Prot: sp|Q9UT12|YLW2_SCHPO Uncharacterized protein P8A3.02c; TrEMBL-Plants: tr|I1M6V8|I1M6V8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0038300 | 10 | ||
| – | 2OG-Fe(II) oxygenase family oxidoreductase; TAIR: AT4G02940.1 oxidoreductase, 2OG-Fe(II) oxygenase family protein; Swiss-Prot: sp|Q01118|SCN7A_HUMAN Sodium channel protein type 7 subunit alpha; TrEMBL-Plants: tr|V7CZP5|V7CZP5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0731100 | 9 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase AlkB like; TAIR: AT3G14160.1 2-oxoglutarate-dependent dioxygenase family protein; Swiss-Prot: sp|P05050|ALKB_ECOLI Alpha-ketoglutarate-dependent dioxygenase AlkB; TrEMBL-Plants: tr|A0A0L9TEQ1|A0A0L9TEQ1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0799900 | 11 | ||
| – | RNA-binding (RRM/RBD/RNP motifs) family protein; TAIR: AT4G20350.2 oxidoreductase; Swiss-Prot: sp|Q3KRA9|ALKB6_HUMAN Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6; TrEMBL-Plants: tr|I3SBA3|I3SBA3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0165400 | 9 | ||
| – | RNA-binding (RRM/RBD/RNP motifs) family protein; TAIR: AT1G31600.1 RNA-binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|Q07G10|ALKB8_XENTR Alkylated DNA repair protein alkB homolog 8; TrEMBL-Plants: tr|I1L5A9|I1L5A9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0351300 | 16 | ||
| – | RNA-binding (RRM/RBD/RNP motifs) family protein; TAIR: AT1G31600.1 RNA-binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|Q07G10|ALKB8_XENTR Alkylated DNA repair protein alkB homolog 8; TrEMBL-Plants: tr|I1L5A9|I1L5A9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0351300 | 16 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase AlkB; TAIR: AT5G01780.2 2-oxoglutarate-dependent dioxygenase family protein; Swiss-Prot: sp|P05050|ALKB_ECOLI Alpha-ketoglutarate-dependent dioxygenase AlkB; TrEMBL-Plants: tr|A0A1J7IJV0|A0A1J7IJV0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0203300 | 16 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase AlkB; TAIR: AT5G01780.5 2-oxoglutarate-dependent dioxygenase family protein; Swiss-Prot: sp|Q5EAC5|ZN410_BOVIN Zinc finger protein 410; TrEMBL-Plants: tr|A0A1J7IJV0|A0A1J7IJV0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0203300 | 14 | ||
| – | Oxidoreductase, 2OG-Fe(II) oxygenase family protein; TAIR: AT1G14710.1 hydroxyproline-rich glycoprotein family protein; Swiss-Prot: sp|P89053|GB_RHCM6 Envelope glycoprotein B; TrEMBL-Plants: tr|A0A0B2R130|A0A0B2R130_GLYSO Uncharacterized protein; Found in the gene: LotjaGi4g1v0357600 | 9 | ||
| – | 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase-like protein; TAIR: AT1G14710.1 hydroxyproline-rich glycoprotein family protein; Swiss-Prot: sp|Q94407|NHR48_CAEEL Nuclear hormone receptor family member nhr-48; TrEMBL-Plants: tr|K7KQ45|K7KQ45_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0357600 | 6 | ||
| – | 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase-like protein; TAIR: AT2G17970.1 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein; Swiss-Prot: sp|Q3TSG4|ALKB5_MOUSE RNA demethylase ALKBH5; TrEMBL-Plants: tr|A0A0R0GNF3|A0A0R0GNF3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0049300 | 10 | ||
| – | 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase-like protein; TAIR: AT2G17970.1 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein; Swiss-Prot: sp|Q08BA6|ALKB5_DANRE RNA demethylase ALKBH5; TrEMBL-Plants: tr|A0A0R0GNF3|A0A0R0GNF3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0049300 | 10 | ||
| – | 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase-like protein; TAIR: AT2G17970.1 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein; Swiss-Prot: sp|Q08BA6|ALKB5_DANRE RNA demethylase ALKBH5; TrEMBL-Plants: tr|A0A0R0GNF3|A0A0R0GNF3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0049300 | 10 | ||
| – | 2OG-Fe(II) oxygenase family oxidoreductase; TAIR: AT4G02940.1 oxidoreductase, 2OG-Fe(II) oxygenase family protein; Swiss-Prot: sp|Q08BA6|ALKB5_DANRE RNA demethylase ALKBH5; TrEMBL-Plants: tr|I1JFD1|I1JFD1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0259300 | 9 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase alkB; TAIR: AT1G11780.1 oxidoreductase, 2OG-Fe(II) oxygenase family protein; Swiss-Prot: sp|Q9SA98|ALKBH_ARATH Alpha-ketoglutarate-dependent dioxygenase alkB; TrEMBL-Plants: tr|I3T319|I3T319_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0097800 | 10 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase alkB like 3; TAIR: AT2G22260.6 oxidoreductase, 2OG-Fe(II) oxygenase family protein; Swiss-Prot: sp|Q9SIE0|ALKB2_ARATH DNA oxidative demethylase ALKBH2; TrEMBL-Plants: tr|I1L044|I1L044_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0282200 | 10 | ||
| – | Alpha-ketoglutarate-dependent dioxygenase alkB like 3; TAIR: AT2G22260.6 oxidoreductase, 2OG-Fe(II) oxygenase family protein; Swiss-Prot: sp|Q9SIE0|ALKB2_ARATH DNA oxidative demethylase ALKBH2; TrEMBL-Plants: tr|I1L044|I1L044_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0282200 | 9 | ||
| – | 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase-like protein; TAIR: AT4G36090.2 oxidoreductase, 2OG-Fe(II) oxygenase family protein; Swiss-Prot: sp|D3ZKD3|ALKB5_RAT RNA demethylase ALKBH5; TrEMBL-Plants: tr|A0A151T7Y1|A0A151T7Y1_CAJCA Alkylated DNA repair protein alkB isogeny 5; Found in the gene: LotjaGi6g1v0360100 | 11 | ||
| – | 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase-like protein; TAIR: AT4G36090.1 oxidoreductase, 2OG-Fe(II) oxygenase family protein; Swiss-Prot: sp|Q3TSG4|ALKB5_MOUSE RNA demethylase ALKBH5; TrEMBL-Plants: tr|A0A151T7Y1|A0A151T7Y1_CAJCA Alkylated DNA repair protein alkB isogeny 5; Found in the gene: LotjaGi6g1v0360100 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 5.26 |