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IPR004733

Source: InterPro

Description

IPR004733 is a Phosphoribosylformylglycinamidine cyclo-ligase.

<p>The purine biosynthetic pathway in prokaryotes enlists eleven enzymes, six of which use ATP. Enzymes 5 and 6 of this pathway, formylglycinamide ribonucleotide (FGAR) amidotransferase (PurL) and aminoimidazole ribonucleotide (AIR) synthetase (PurM or AIRS) utilise ATP to activate the oxygen of an amide within their substrate toward nucleophilic attack by a nitrogen. PurM (also known as phosphoribosyl-aminoimidazole synthetase or phosphoribosylformylglycinamidine cyclo-ligase) uses the product of PurL, formylglycinamidine ribonucleotide (FGAM) and ATP to make AIR, ADP and P(i) [[cite:PUB00074111], [cite:PUB00014643]]. The N-terminal domain of PurM is related to the ATP-binding domains of hydrogen expression/formation protein HypE, the AIR synthases, selenophosphate synthetase (SelD), and FGAM synthase and is thought to bind ATP [[cite:PUB00080725]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004641
Molecular function Phosphoribosylformylglycinamidine cyclo-ligase activity Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate.
Subterm of
GO:0006189
Biological process 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
Subterm of

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
Lj0g3v0241679.1
– PREDICTED: phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial-like [Glycine max] gi|356512850|ref|XP_003525128.1|
Domains
12
Lj0g3v0241679.2
– RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial; AltName: Full=AIR synthase; Short=AIRS; AltName: Full=Phosphoribosyl-aminoimidazole synthetase; AltName: Full=VUpur5; Flags: Precursorgi|945060|gb|AAC14578.1| aminoimidazole ribonucleotide (AIRS) synthetase [Vigna unguiculata] gi|1709925|sp|P52424.1|PUR5_VIGUN
Domains
13
Lj4g3v2742680.1
– PREDICTED: phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial-like [Glycine max] gi|356512850|ref|XP_003525128.1|
Domains
12
Lj4g3v2742680.2
– RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial; AltName: Full=AIR synthase; Short=AIRS; AltName: Full=Phosphoribosyl-aminoimidazole synthetase; AltName: Full=VUpur5; Flags: Precursorgi|945060|gb|AAC14578.1| aminoimidazole ribonucleotide (AIRS) synthetase [Vigna unguiculata] gi|1709925|sp|P52424.1|PUR5_VIGUN
Domains
13
LotjaGi4g1v0410200.2
– Phosphoribosylformylglycinamidine cyclo-ligase; TAIR: AT3G55010.1 phosphoribosylformylglycinamidine cyclo-ligase, chloroplast / phosphoribosyl-aminoimidazole synthetase / AIR synthase (PUR5); Swiss-Prot: sp|P52424|PUR5_VIGUN Phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A0L9TJC7|A0A0L9TJC7_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0410200
Domains
16
LotjaGi5g1v0315300.1
– Phosphoribosylformylglycinamidine cyclo-ligase; TAIR: AT3G55010.1 phosphoribosylformylglycinamidine cyclo-ligase, chloroplast / phosphoribosyl-aminoimidazole synthetase / AIR synthase (PUR5); Swiss-Prot: sp|P52424|PUR5_VIGUN Phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A0L9TJC7|A0A0L9TJC7_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0315300
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd02196 CDD 1 16.67