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IPR016188 is a PurM-like, N-terminal domain.
<p>This entry represents a structural domain with a core structure consisting of β-α-β-α-β(2), which is found in two enzymes of the purine biosynthetic pathway: at the N-terminal of aminoimidazole ribonucleotide (AIR) synthetase (PurM) [[cite:PUB00014643]], as well as the N1 and N2 domains of formylglycinamide ribonucleotide (FGAR) amidotransferase (PurL) (PurM-like module) [[cite:PUB00016818]]. PurM and PurL utilise ATP to activate the oxygen of an amide within their substrate toward nucleophilic attack by a nitrogen. PurM uses the product of PurL, formylglycinamidine ribonucleotide (FGAM) and ATP to make AIR, ADP and P(i). It is also found as domains 1 and 3 in phosphoribosylformylglycinamidine synthase II (smPurL) ([ec:6.3.5.3]) (carries a duplication: tandem repeats of two PurM-like units arranged like the PurM subunits in the dimer) [[cite:PUB00037958]].</p> <p>This domain is also found at the N-terminal of thiamine monophosphate kinase ([ec:2.7.4.16]) (ThiL) [[cite:PUB00016093]]. ThiL phosphorylates thiamine monophosphate to form thiamine pyrophosphate, an essential cofactor that is synthesized de novo by Salmonella typhimurium.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial-like [Glycine max] gi|356512850|ref|XP_003525128.1| | 12 | ||
| – | RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial; AltName: Full=AIR synthase; Short=AIRS; AltName: Full=Phosphoribosyl-aminoimidazole synthetase; AltName: Full=VUpur5; Flags: Precursorgi|945060|gb|AAC14578.1| aminoimidazole ribonucleotide (AIRS) synthetase [Vigna unguiculata] gi|1709925|sp|P52424.1|PUR5_VIGUN | 13 | ||
| – | PREDICTED: probable phosphoribosylformylglycinamidine synthase, chloroplastic/mitochondrial-like [Cicer arietinum] gi|502138893|ref|XP_004503568.1| | 12 | ||
| – | PREDICTED: probable phosphoribosylformylglycinamidine synthase, chloroplastic/mitochondrial-like [Cicer arietinum] gi|502138893|ref|XP_004503568.1| | 7 | ||
| – | PREDICTED: phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial-like [Glycine max] gi|356512850|ref|XP_003525128.1| | 12 | ||
| – | RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial; AltName: Full=AIR synthase; Short=AIRS; AltName: Full=Phosphoribosyl-aminoimidazole synthetase; AltName: Full=VUpur5; Flags: Precursorgi|945060|gb|AAC14578.1| aminoimidazole ribonucleotide (AIRS) synthetase [Vigna unguiculata] gi|1709925|sp|P52424.1|PUR5_VIGUN | 13 | ||
| – | RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial; AltName: Full=AIR synthase; Short=AIRS; AltName: Full=Phosphoribosyl-aminoimidazole synthetase; AltName: Full=VUpur5; Flags: Precursorgi|945060|gb|AAC14578.1| aminoimidazole ribonucleotide (AIRS) synthetase [Vigna unguiculata] gi|1709925|sp|P52424.1|PUR5_VIGUN | 5 | ||
| – | Phosphoribosylformylglycinamidine cyclo-ligase; TAIR: AT3G55010.1 phosphoribosylformylglycinamidine cyclo-ligase, chloroplast / phosphoribosyl-aminoimidazole synthetase / AIR synthase (PUR5); Swiss-Prot: sp|P52424|PUR5_VIGUN Phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A0L9TJC7|A0A0L9TJC7_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0410200 | 16 | ||
| – | Phosphoribosylformylglycinamidine cyclo-ligase; TAIR: AT3G55010.1 phosphoribosylformylglycinamidine cyclo-ligase, chloroplast / phosphoribosyl-aminoimidazole synthetase / AIR synthase (PUR5); Swiss-Prot: sp|P52424|PUR5_VIGUN Phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A0L9TJC7|A0A0L9TJC7_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0315300 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02196 | CDD | 1 | 11.11 |