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IPR004739

Source: InterPro

Description

IPR004739 is a GMP synthase, glutamine amidotransferase.

<p>This entry represents the N-terminal domain of bacterial GMP synthase [glutamine-hydrolyzing] [ec:6.3.5.2] and similar sequences found in all cellular organisms. This domain covers the whole protein length in some archaeal members of this group.</p> <p> GMP synthase catalyses the synthesis of GMP from XMP [[cite:PUB00002406], [cite:PUB00002062]]. <reaction> ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate</reaction></p> <p>GMP synthetase is a glutamine amidotransferase from the de novo purine biosynthetic pathway. It belongs to the triad family of amidotransferases having a conserved Cys-His-Glu catalytic triad in the glutaminase active site [[cite:PUB00003933]].</p> <p>Glutamine amidotransferase (GATase) activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003922
Molecular function GMP synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.
Subterm of
GO:0005524
Molecular function ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
Subterm of
GO:0006177
Biological process GMP biosynthetic process The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj4g3v2963440.1
– PREDICTED: GMP synthase [glutamine]-hydrolyzing] gi|502139270|ref|XP_004503710.1|
Domains
26
LotjaGi4g1v0426900.1
– GMP synthase [glutamine]-hydrolyzing] protein; TAIR: AT1G63660.1 GMP synthase (glutamine-hydrolyzing), putative / glutamine amidotransferase; Swiss-Prot: sp|Q89N53|GUAA_BRADU GMP synthase [glutamine]-hydrolyzing]; TrEMBL-Plants: tr|A0A0L9VPW7|A0A0L9VPW7_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0426900
Domains
26

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd01997 CDD 1 50.00