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IPR004803 is a tRNA-guanine transglycosylase.
<p>Queuine is a hypermodified base that occurs in the wobble position of the anticodon of tRNAs Asp, Asn, His and Tyr. Queuine is incorporated into tRNA via a base exchange reaction with guanine catalysed by queuine tRNA-ribosyltransferase (also known as tRNA-guanine transglycosylase). In eukaryotes, queuine is directly exchanged into tRNA while in eubacteria, a queuine precursor (preQ1) is incorporated and ultimately modified to queuine [[cite:PUB00046129], [cite:PUB00046130]]. Archaea contain a closely related enzyme ([interpro:IPR004804]) that catalyses a base exchange of guanine for an archaeosine precursor [[cite:PUB00046131]]. This precursor is then subsequently converted to the archaeal-specific modified base archaeosine. Some archaea, such as Archaeoglobus fulgidus, contain both these enzymes.</p> <p>The eukaryotic tRNA-guanine transglycosylase exists as a heterodimer of a catalytic subunit (QTRT1) and another subunit known as queuine tRNA-ribosyltransferase domain-containing 1 (QTRTD1), whereas the eubacteria enzyme is homodimeric [[cite:PUB00082327], [cite:PUB00082328]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Queuine tRNA-ribosyltransferase activity | Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine. | ||
| Biological process | TRNA-guanine transglycosylation | The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: queuine tRNA-ribosyltransferase-like [Glycine max] gi|356510157|ref|XP_003523806.1| | 10 | ||
| – | PREDICTED: queuine tRNA-ribosyltransferase-like [Glycine max] gi|356510157|ref|XP_003523806.1| | 10 | ||
| – | Queuine tRNA-ribosyltransferase; TAIR: AT1G72430.1 SAUR-like auxin-responsive protein family; Swiss-Prot: sp|Q28HC6|TGT_XENTR Queuine tRNA-ribosyltransferase catalytic subunit 1; TrEMBL-Plants: tr|A0A0R0JIE5|A0A0R0JIE5_SOYBN Queuine tRNA-ribosyltransferase catalytic subunit 1; Found in the gene: LotjaGi1g1v0340000 | 11 | ||
| – | Queuine tRNA-ribosyltransferase; TAIR: AT3G26700.1 Protein kinase superfamily protein; Swiss-Prot: sp|Q28HC6|TGT_XENTR Queuine tRNA-ribosyltransferase catalytic subunit 1; TrEMBL-Plants: tr|A0A0R0KCQ4|A0A0R0KCQ4_SOYBN Queuine tRNA-ribosyltransferase catalytic subunit 1; Found in the gene: LotjaGi1g1v0340000 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00449 | TIGRFAM | 1 | 25.00 |