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IPR005043 is a Exportin-2, C-terminal.
<p>Exportin-2, also known as CAS, is an export receptor for importin-alpha [[cite:PUB00007252]]. It binds strongly to importin alpha only in the presence of RanGTP, forming an importin alpha/CAS/RanGTP complex. Exportin-2 mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm [[cite:PUB00090423]].</p> <p>This entry represents the C-terminal domain of XPO2. Structural studies of its yeast homologue, Cse1, indicate that this domain binds to both the transport-orchestrating protein RanGTP and the cargo molecule that is being exported [[cite:PUB00032221]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Protein binding | Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). | ||
| Molecular function | Ran GTPase binding | Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: exportin-2-like isoform 1 [Glycine max] gi|356560135|ref|XP_003548351.1| | 14 | ||
| – | Exportin-2; TAIR: AT2G46520.1 cellular apoptosis susceptibility protein, putative / importin-alpha re-exporter; Swiss-Prot: sp|Q9ZPY7|XPO2_ARATH Exportin-2; TrEMBL-Plants: tr|K7MET7|K7MET7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0396900 | 14 | ||
| – | Exportin-2; TAIR: AT2G46520.1 cellular apoptosis susceptibility protein, putative / importin-alpha re-exporter; Swiss-Prot: sp|Q9ZPY7|XPO2_ARATH Exportin-2; TrEMBL-Plants: tr|K7MET7|K7MET7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0396900 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF48371 | SUPERFAMILY | 1 | 33.33 |