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IPR001494 is a Importin-beta, N-terminal domain.
<p>This entry represents the N-terminal domain of importin-beta (also known as karyopherins-beta) that is important for the binding of the Ran GTPase protein [[cite:PUB00018160]].</p> <p>Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins [[cite:PUB00009772], [cite:PUB00034678]], which is important for importin-beta mediated transport.</p> <p>Ran GTPase helps to control the unidirectional transfer of cargo. The cytoplasm contains primarily RanGDP and the nucleus RanGTP through the actions of RanGAP and RanGEF, respectively. In the nucleus, RanGTP binds to importin-beta within the importin/cargo complex, causing a conformational change in importin-beta that releases it from importin-alpha-bound cargo. As a result, the N-terminal auto-inhibitory region on importin-alpha is free to loop back and bind to the major NLS-binding site, causing the cargo to be released [[cite:PUB00034676]]. There are additional release factors as well.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Biological process | Intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. | ||
Molecular function | Ran GTPase binding | Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: probable importin-7 homolog isoform X1 [Cicer arietinum] gi|502102327|ref|XP_004492039.1| | 11 | ||
– | PREDICTED: transportin-3-like isoform 2 [Glycine max] gi|356562789|ref|XP_003549651.1| | 10 | ||
– | PREDICTED: importin subunit beta-1-like [Cicer arietinum] gi|502136423|ref|XP_004502681.1| | 13 | ||
– | PREDICTED: importin-11-like [Glycine max] gi|356568126|ref|XP_003552264.1| | 11 | ||
– | PREDICTED: importin-11-like [Glycine max] gi|356568126|ref|XP_003552264.1| | 9 | ||
– | PREDICTED: exportin-2-like isoform 1 [Glycine max] gi|356560135|ref|XP_003548351.1| | 14 | ||
– | PREDICTED: exportin-1-like isoform 1 [Glycine max] gi|356538463|ref|XP_003537723.1| | 14 | ||
– | PREDICTED: exportin-1-like isoform 1 [Glycine max] gi|356538463|ref|XP_003537723.1| | 14 | ||
– | ARM repeat superfamily protein [Theobroma cacao] gi|508714972|gb|EOY06869.1| | 13 | ||
– | PREDICTED: importin-5-like isoform X2 [Cicer arietinum] gi|502140730|ref|XP_004504314.1| | 16 | ||
– | PREDICTED: importin subunit beta-1-like [Glycine max] gi|356523655|ref|XP_003530452.1| | 13 | ||
– | PREDICTED: transportin-1-like isoform 1 [Glycine max] gi|356536398|ref|XP_003536725.1| | 13 | ||
– | PREDICTED: probable importin subunit beta-4-like [Glycine max] gi|356558485|ref|XP_003547537.1| | 16 | ||
– | Importin subunit beta-1; TAIR: AT5G53480.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9FJD4|IMB1_ARATH Importin subunit beta-1; TrEMBL-Plants: tr|V7ASE2|V7ASE2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0289100 | 13 | ||
– | Importin subunit beta-1; TAIR: AT5G53480.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9FJD4|IMB1_ARATH Importin subunit beta-1; TrEMBL-Plants: tr|V7ASE2|V7ASE2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0289100 | 13 | ||
– | Importin-like protein; TAIR: AT3G08960.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9UI26|IPO11_HUMAN Importin-11; TrEMBL-Plants: tr|K7MTL7|K7MTL7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0443600 | 9 | ||
– | Importin-like protein; TAIR: AT3G08960.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9UI26|IPO11_HUMAN Importin-11; TrEMBL-Plants: tr|K7MTL7|K7MTL7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0443600 | 9 | ||
– | Importin-like protein; TAIR: AT3G08960.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9UI26|IPO11_HUMAN Importin-11; TrEMBL-Plants: tr|K7MTL7|K7MTL7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0443600 | 8 | ||
– | Importin-like protein; TAIR: AT3G08960.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9UI26|IPO11_HUMAN Importin-11; TrEMBL-Plants: tr|K7MTL7|K7MTL7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0443600 | 9 | ||
– | Importin-like protein; TAIR: AT2G31660.1 ARM repeat superfamily protein; Swiss-Prot: sp|F4IRR2|SAD2_ARATH Importin beta-like SAD2; TrEMBL-Plants: tr|I1N4Z0|I1N4Z0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0529600 | 19 | ||
– | Importin-like protein; TAIR: AT2G31660.1 ARM repeat superfamily protein; Swiss-Prot: sp|F4IRR2|SAD2_ARATH Importin beta-like SAD2; TrEMBL-Plants: tr|I1N4Z0|I1N4Z0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0529600 | 19 | ||
– | Importin-like protein; TAIR: AT2G31660.1 ARM repeat superfamily protein; Swiss-Prot: sp|F4IRR2|SAD2_ARATH Importin beta-like SAD2; TrEMBL-Plants: tr|I1N4Z0|I1N4Z0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0547000 | 12 | ||
– | Importin-like protein; TAIR: AT3G59020.1 ARM repeat superfamily protein; Swiss-Prot: sp|F4J738|SAD2H_ARATH Importin beta-like SAD2 homolog; TrEMBL-Plants: tr|V7B088|V7B088_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0547000 | 12 | ||
– | Importin-like protein; TAIR: AT3G59020.2 ARM repeat superfamily protein; Swiss-Prot: sp|F4J738|SAD2H_ARATH Importin beta-like SAD2 homolog; TrEMBL-Plants: tr|V7B088|V7B088_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0547200_LC | 12 | ||
– | Importin-like protein; TAIR: AT3G59020.2 ARM repeat superfamily protein; Swiss-Prot: sp|F4J738|SAD2H_ARATH Importin beta-like SAD2 homolog; TrEMBL-Plants: tr|V7B088|V7B088_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0547200_LC | 12 | ||
– | Exportin-7; TAIR: AT5G06120.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q5ZLT0|XPO7_CHICK Exportin-7; TrEMBL-Plants: tr|A0A0L9UHI4|A0A0L9UHI4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0557800 | 9 | ||
– | Importin 9; TAIR: AT1G26170.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q91YE6|IPO9_MOUSE Importin-9; TrEMBL-Plants: tr|A0A072TJ92|A0A072TJ92_MEDTR Importin 9; Found in the gene: LotjaGi2g1v0285500 | 7 | ||
– | Exportin-1; TAIR: AT5G17020.1 exportin 1A; Swiss-Prot: sp|Q9SMV6|XPO1A_ARATH Protein EXPORTIN 1A; TrEMBL-Plants: tr|A0A0S3SEC4|A0A0S3SEC4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0449000 | 24 | ||
– | Exportin-1; TAIR: AT5G17020.1 exportin 1A; Swiss-Prot: sp|Q9SMV6|XPO1A_ARATH Protein EXPORTIN 1A; TrEMBL-Plants: tr|A0A0S3SEC4|A0A0S3SEC4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0449000 | 13 | ||
– | Exportin-1; TAIR: AT5G17020.1 exportin 1A; Swiss-Prot: sp|Q9SMV6|XPO1A_ARATH Protein EXPORTIN 1A; TrEMBL-Plants: tr|A0A0S3SEC4|A0A0S3SEC4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0449000 | 24 | ||
– | Exportin-1; TAIR: AT5G17020.1 exportin 1A; Swiss-Prot: sp|Q9SMV6|XPO1A_ARATH Protein EXPORTIN 1A; TrEMBL-Plants: tr|A0A0S3SEC4|A0A0S3SEC4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0449000 | 24 | ||
– | Exportin-1; TAIR: AT5G17020.1 exportin 1A; Swiss-Prot: sp|Q9SMV6|XPO1A_ARATH Protein EXPORTIN 1A; TrEMBL-Plants: tr|A0A0S3SEC4|A0A0S3SEC4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0449000 | 13 | ||
– | Exportin-1; TAIR: AT5G17020.2 exportin 1A; Swiss-Prot: sp|Q9SMV6|XPO1A_ARATH Protein EXPORTIN 1A; TrEMBL-Plants: tr|A0A0L9V7V7|A0A0L9V7V7_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0449000 | 24 | ||
– | Exportin-1; TAIR: AT5G17020.1 exportin 1A; Swiss-Prot: sp|Q9SMV6|XPO1A_ARATH Protein EXPORTIN 1A; TrEMBL-Plants: tr|A0A0S3SEC4|A0A0S3SEC4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0449000 | 24 | ||
– | Exportin-2; TAIR: AT2G46520.1 cellular apoptosis susceptibility protein, putative / importin-alpha re-exporter; Swiss-Prot: sp|Q9ZPY7|XPO2_ARATH Exportin-2; TrEMBL-Plants: tr|K7MET7|K7MET7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0396900 | 14 | ||
– | Exportin-2; TAIR: AT2G46520.1 cellular apoptosis susceptibility protein, putative / importin-alpha re-exporter; Swiss-Prot: sp|Q9ZPY7|XPO2_ARATH Exportin-2; TrEMBL-Plants: tr|K7MET7|K7MET7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0396900 | 14 | ||
– | Exportin-1; TAIR: AT5G17020.1 exportin 1A; Swiss-Prot: sp|Q9SMV6|XPO1A_ARATH Protein EXPORTIN 1A; TrEMBL-Plants: tr|I1LII4|I1LII4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0538500 | 21 | ||
– | Exportin-1; TAIR: AT5G17020.1 exportin 1A; Swiss-Prot: sp|Q9SMV6|XPO1A_ARATH Protein EXPORTIN 1A; TrEMBL-Plants: tr|K7LSJ2|K7LSJ2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0538500 | 12 | ||
– | Exportin-1; TAIR: AT5G17020.1 exportin 1A; Swiss-Prot: sp|Q9SMV6|XPO1A_ARATH Protein EXPORTIN 1A; TrEMBL-Plants: tr|I1LII4|I1LII4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0538500 | 24 | ||
– | Transportin-3; TAIR: AT5G62600.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q8GUL2|MOS14_ARATH Transportin MOS14; TrEMBL-Plants: tr|A0A0L9TRZ7|A0A0L9TRZ7_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0242600 | 10 | ||
– | Importin beta-like SAD2-like protein; TAIR: AT3G17340.1 ARM repeat superfamily protein; Swiss-Prot: sp|F4J738|SAD2H_ARATH Importin beta-like SAD2 homolog; TrEMBL-Plants: tr|A0A151SSC8|A0A151SSC8_CAJCA Putative importin-7 isogeny; Found in the gene: LotjaGi4g1v0311900 | 9 | ||
– | Importin beta-like SAD2-like protein; TAIR: AT3G17340.1 ARM repeat superfamily protein; Swiss-Prot: sp|F4J738|SAD2H_ARATH Importin beta-like SAD2 homolog; TrEMBL-Plants: tr|I1MRW2|I1MRW2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0311900 | 10 | ||
– | Importin-5; TAIR: AT5G19820.1 ARM repeat superfamily protein; Swiss-Prot: sp|O00410|IPO5_HUMAN Importin-5; TrEMBL-Plants: tr|I1KSC8|I1KSC8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0376600 | 17 | ||
– | Importin subunit beta-1; TAIR: AT5G53480.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9FJD4|IMB1_ARATH Importin subunit beta-1; TrEMBL-Plants: tr|I1KPN2|I1KPN2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0437800 | 13 | ||
– | Importin subunit beta-1; TAIR: AT5G53480.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9FJD4|IMB1_ARATH Importin subunit beta-1; TrEMBL-Plants: tr|I1KPN2|I1KPN2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0437800 | 13 | ||
– | Importin beta-1, putative; TAIR: AT2G16950.2 transportin 1; Swiss-Prot: sp|Q8H0U4|TNPO1_ARATH Transportin-1; TrEMBL-Plants: tr|A0A151TQB2|A0A151TQB2_CAJCA Transportin-1; Found in the gene: LotjaGi5g1v0350400 | 14 | ||
– | Importin beta-1, putative; TAIR: AT2G16950.2 transportin 1; Swiss-Prot: sp|Q8H0U4|TNPO1_ARATH Transportin-1; TrEMBL-Plants: tr|A0A0B2RSI8|A0A0B2RSI8_GLYSO Transportin-1; Found in the gene: LotjaGi5g1v0350400 | 10 | ||
– | Transportin-1; TAIR: AT2G16950.2 transportin 1; Swiss-Prot: sp|Q8H0U4|TNPO1_ARATH Transportin-1; TrEMBL-Plants: tr|A0A151TQB2|A0A151TQB2_CAJCA Transportin-1; Found in the gene: LotjaGi5g1v0350400 | 11 | ||
– | Importin beta-1, putative; TAIR: AT2G16950.2 transportin 1; Swiss-Prot: sp|Q8H0U4|TNPO1_ARATH Transportin-1; TrEMBL-Plants: tr|A0A151TQB2|A0A151TQB2_CAJCA Transportin-1; Found in the gene: LotjaGi5g1v0350400 | 12 | ||
– | Importin-like protein; TAIR: AT2G31660.1 ARM repeat superfamily protein; Swiss-Prot: sp|F4IRR2|SAD2_ARATH Importin beta-like SAD2; TrEMBL-Plants: tr|I1KWS2|I1KWS2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0365400 | 14 | ||
– | Importin-like protein; TAIR: AT2G31660.1 ARM repeat superfamily protein; Swiss-Prot: sp|F4IRR2|SAD2_ARATH Importin beta-like SAD2; TrEMBL-Plants: tr|I1KWS2|I1KWS2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0365400 | 14 | ||
– | Importin beta; TAIR: AT4G27640.1 ARM repeat superfamily protein; Swiss-Prot: sp|O60100|IMB4_SCHPO Probable importin subunit beta-4; TrEMBL-Plants: tr|K7M9M1|K7M9M1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0360700 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
SSF48371 | SUPERFAMILY | 1 | 1.92 |