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IPR005215 is a Trigger factor.
<p>The trigger factor is found in several prokaryotes, and is involved in protein export. Trigger factor is a ribosome-associated molecular chaperone and is the first chaperone to interact with nascent polypeptide. It acts as a chaperone by maintaining the newly synthesised protein in an open conformation. It consists of three domains, an N-terminal ribosome-binding domain (RBD), a central peptidyl-prolyl cis/trans isomerase (PPIase) domain and a C-terminal substrate-binding domain (SBD) which is stabilised by a linker between the RBD and PPIase domains [[cite:PUB00015317], [cite:PUB00038013], [cite:PUB00099906]]. The association between its N-terminal domain with the ribosomal protein L23 located next to the peptide tunnel exit is essential for the interaction with nascent polypeptides and its in vivo function. Trigger factor can bind at the same time as the signal recognition particle (SRP), but is excluded by the SRP receptor (FtsY) [[cite:PUB00015317]].</p> <p>The trigger factor-like protein included in this entry can be found in plant chloroplasts, where it may be involved in protein export.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Trigger factor; TAIR: AT5G55220.1 trigger factor type chaperone family protein; Swiss-Prot: sp|Q8S9L5|TIG_ARATH Trigger factor-like protein TIG, Chloroplastic; TrEMBL-Plants: tr|I1JJE0|I1JJE0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0024000 | 23 | ||
| – | Trigger factor; TAIR: AT2G30695.1 bacterial trigger factor; Swiss-Prot: sp|Q9UTE6|MAK16_SCHPO Protein mak16; TrEMBL-Plants: tr|A0A151QRF8|A0A151QRF8_CAJCA Trigger factor; Found in the gene: LotjaGi3g1v0329800_LC | 3 | ||
| – | Trigger factor; TAIR: AT2G30695.4 bacterial trigger factor; Swiss-Prot: sp|Q9UTE6|MAK16_SCHPO Protein mak16; TrEMBL-Plants: tr|I1JVQ5|I1JVQ5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0329800_LC | 3 | ||
| – | Trigger factor-like protein, putative; TAIR: AT2G30695.1 bacterial trigger factor; Swiss-Prot: sp|Q5N1P5|TIG_SYNP6 Trigger factor; TrEMBL-Plants: tr|I3S2E8|I3S2E8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0501900 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SignalP-TM | SignalP_GRAM_NEGATIVE | 1 | 25.00 |