Description

IPR027304 is a Trigger factor/SurA domain superfamily.

<p>The C-terminal domain of trigger factor and the peptide-binding domain of porin chaperone SurA share a multi-helical structure consisting of an irregular array of long and short helices.</p> <p>In the Escherichia coli cytosol, a fraction of the newly synthesised proteins requires the activity of molecular chaperones for folding to the native state. The major chaperones implicated in this folding process are the ribosome-associated Trigger Factor (TF), and the DnaK and GroEL chaperones with their respective co-chaperones. Trigger Factor is an ATP-independent chaperone and displays chaperone and peptidyl-prolyl-cis-trans-isomerase (PPIase) activities<i>in vitro</i>. It is composed of three domains, an N-terminal domain which mediates association with the large ribosomal subunit, a central PPIase domain with homology to FKBP proteins, and a C-terminal substrate-binding domain [[cite:PUB00011507], [cite:PUB00099906]]. The association between its N-terminal domain with the ribosomal protein L23 located next to the peptide tunnel exit is essential for the interaction with nascent polypeptides and its in vivo function [[cite:PUB00011507], [cite:PUB00099906]].</p> <p>The porin chaperon SurA facilitates correct folding of outer membrane proteins in Gram-negative bacteria [[cite:PUB00028929], [cite:PUB00099907]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 2

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: