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IPR005251 is a Methylthioribose-1-phosphate isomerase.
<p>This family contains proteins designated as 5-methylthioribose-1-phosphate isomerase (MTNA, [ec:5.3.1.23], [[cite:PUB00016716]]). It also contains putative translation initiation factor 2B subunit proteins.</p> <p>5-methylthioribose-1-phosphate isomerase (MTNA) participates in the methionine salvage pathway catalysing the isomerisation of 5-methylthioribose-1-phosphate to 5-methylthio ribulose-1-phosphate [[cite:PUB00016714]]. The methionine salvage pathway leads to the synthesis of methionine from methylthioadenosine, the end product of the spermidine and spermine anabolism in many species.</p> <p>The delineation of this family is based in part on a discussion and neighbour-joining phylogenetic study [[cite:PUB00004919], [cite:PUB00016925]], of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. The archaeal proteins are related to the common ancestor of eIF-2B alpha, beta, and delta rather then specifically to any one of them, and that designation of particular archaeal members as corresponding to eIF-2B alpha or eIF-2B delta is imprecise. It has been suggested that designating the archaeal proteins as translation initiation factors remains unproven.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Cellular biosynthetic process | The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: methylthioribose-1-phosphate isomerase-like [Cicer arietinum] gi|502086014|ref|XP_004488081.1| | 13 | ||
| – | Methylthioribose-1-phosphate isomerase; TAIR: AT2G05830.1 NagB/RpiA/CoA transferase-like superfamily protein; Swiss-Prot: sp|B9HCR2|MTNA_POPTR Methylthioribose-1-phosphate isomerase; TrEMBL-Plants: tr|G7IGG7|G7IGG7_MEDTR Methylthioribose-1-phosphate isomerase; Found in the gene: LotjaGi6g1v0223700 | 14 | ||
| – | Methylthioribose-1-phosphate isomerase; TAIR: AT2G05830.1 NagB/RpiA/CoA transferase-like superfamily protein; Swiss-Prot: sp|B9HCR2|MTNA_POPTR Methylthioribose-1-phosphate isomerase; TrEMBL-Plants: tr|A0A151RME1|A0A151RME1_CAJCA Methylthioribose-1-phosphate isomerase; Found in the gene: LotjaGi6g1v0223700 | 15 | ||
| – | Methylthioribose-1-phosphate isomerase; TAIR: AT2G05830.1 NagB/RpiA/CoA transferase-like superfamily protein; Swiss-Prot: sp|B9HCR2|MTNA_POPTR Methylthioribose-1-phosphate isomerase; TrEMBL-Plants: tr|G7IGG7|G7IGG7_MEDTR Methylthioribose-1-phosphate isomerase; Found in the gene: LotjaGi6g1v0223700 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00524 | TIGRFAM | 1 | 25.00 |