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IPR005302 is a Molybdenum cofactor sulfurase, C-terminal.
<p>Molybdenum cofactor (MOCO) sulphurases [[cite:PUB00034759]] catalyse the insertion of a terminal sulphur ligand into the molybdenum cofactor, thereby converting the oxo form of MOCO to a sulphurylated form. Suphurylated MOCO is required by several enzymes, including: aldehyde oxidase ([ec:1.2.3.1]), which function in the last step of abscisic acid biosynthesis in plants [[cite:PUB00035521]]; and xanthine dehydrogenase ([ec:1.17.1.4]), which synthesis uric acid from xanthine during nitrogen metabolism [[cite:PUB00035522]].</p> <p>This entry represents the β-barrel C-terminal domain of MOCO sulphurase (MOSC domain), which has a β-barrel structure similar to that of the β-barrel domain in pyruvate kinase and contains a highly conserved cysteine residue required for activity. MOSC domains are found in several diverse metal-sulphur cluster biosynthesis proteins from both eukaryotes and prokaryotes. MOSC domains occur as either stand-alone forms, such as the YiiM protein from Escherichia coli, or fused to other domains, such as a NifS-like catalytic domain in MOCO sulphurase. The MOSC domain is predicted to be a sulphur-carrier domain that receives sulphur abstracted from pyridoxal phosphate-dependent NifS-like enzymes, on its conserved cysteine, and delivers it for the formation of diverse sulphur-metal clusters [[cite:PUB00019067]].</p> <p>The MOSC domain contains several patches of hydrophobic residues and an absolutely conserved cysteine residue situated closer to the C-terminal end of the domain. The absolutely conserved cysteine in the MOSC domain is reminiscent of the analogous conservation of a cysteine in the active site of the thioredoxin and rhodanese superfamilies. Members of both these superfamilies, especially of the latter one, have been implicated in the synthesis of Fe-S clusters, through mobilisation of sulphur with their active cysteine.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Catalytic activity | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. | ||
| Molecular function | Molybdenum ion binding | Interacting selectively and non-covalently with molybdenum (Mo) ions. | ||
| Molecular function | Pyridoxal phosphate binding | Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: molybdenum cofactor sulfurase-like [Cicer arietinum] gi|502146463|ref|XP_004506463.1| | 18 | ||
| – | PREDICTED: MOSC domain-containing protein 2, mitochondrial-like [Cicer arietinum] gi|502085355|ref|XP_004487898.1| | 16 | ||
| – | Molybdenum cofactor sulfurase [Medicago truncatula] gi|357449163|ref|XP_003594858.1| | 11 | ||
| – | Molybdenum cofactor sulfurase; TAIR: AT1G16540.1 molybdenum cofactor sulfurase (LOS5) (ABA3); Swiss-Prot: sp|Q9C5X8|MOCOS_ARATH Molybdenum cofactor sulfurase; TrEMBL-Plants: tr|I1KZR5|I1KZR5_SOYBN Molybdenum cofactor sulfurase; Found in the gene: LotjaGi3g1v0054500 | 19 | ||
| – | Molybdenum cofactor sulfurase; TAIR: AT1G16540.1 molybdenum cofactor sulfurase (LOS5) (ABA3); Swiss-Prot: sp|Q9C5X8|MOCOS_ARATH Molybdenum cofactor sulfurase; TrEMBL-Plants: tr|K7LB25|K7LB25_SOYBN Molybdenum cofactor sulfurase; Found in the gene: LotjaGi3g1v0054500 | 18 | ||
| – | Molybdenum cofactor sulfurase family protein; TAIR: AT1G30910.1 Molybdenum cofactor sulfurase family protein; Swiss-Prot: sp|Q5VT66|MARC1_HUMAN Mitochondrial amidoxime-reducing component 1; TrEMBL-Plants: tr|I3SXQ0|I3SXQ0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0244900 | 11 | ||
| – | Molybdenum cofactor sulfurase family protein; TAIR: AT1G30910.1 Molybdenum cofactor sulfurase family protein; Swiss-Prot: sp|O88994|MARC2_RAT Mitochondrial amidoxime reducing component 2; TrEMBL-Plants: tr|I3SXQ0|I3SXQ0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0245000 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SignalP-TM | SignalP_GRAM_NEGATIVE | 1 | 14.29 |