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IPR005303 is a Molybdenum cofactor sulfurase, middle domain.
<p>This entry represents a domain located in the middle of Molybdenum cofactor sulfurases (MOCOS). MOCOS sulfurates the molybdenum cofactor [[cite:PUB00103855]]. Mutations in this protein lead to a disorder characterised by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones [[cite:PUB00069600]].</p> <p>This domain is also found at the N-terminal end of Mitochondrial amidoxime-reducing component 1 (mARC1), which catalyses the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles [[cite:PUB00103854], [cite:PUB00103856]], This protein comprises two structural domains which consist of non successive secondary-structure element, with mainly β-strands forming three- and four-stranded antiparallel β-sheets and several α-helices of different lengths [[cite:PUB00103857]].</p> <p>This domain, also known as the MOSC_N domain, is often found to the N terminus of MOSC domain ([interpro:IPR005302]).</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: molybdenum cofactor sulfurase-like [Cicer arietinum] gi|502146463|ref|XP_004506463.1| | 18 | ||
| – | PREDICTED: MOSC domain-containing protein 2, mitochondrial-like [Cicer arietinum] gi|502085355|ref|XP_004487898.1| | 16 | ||
| – | Molybdenum cofactor sulfurase [Medicago truncatula] gi|357449163|ref|XP_003594858.1| | 11 | ||
| – | Molybdenum cofactor sulfurase-like protein [Medicago truncatula] gi|357449165|ref|XP_003594859.1| | 6 | ||
| – | Molybdenum cofactor sulfurase; TAIR: AT1G16540.1 molybdenum cofactor sulfurase (LOS5) (ABA3); Swiss-Prot: sp|Q9C5X8|MOCOS_ARATH Molybdenum cofactor sulfurase; TrEMBL-Plants: tr|I1KZR5|I1KZR5_SOYBN Molybdenum cofactor sulfurase; Found in the gene: LotjaGi3g1v0054500 | 19 | ||
| – | Molybdenum cofactor sulfurase; TAIR: AT1G16540.1 molybdenum cofactor sulfurase (LOS5) (ABA3); Swiss-Prot: sp|Q9C5X8|MOCOS_ARATH Molybdenum cofactor sulfurase; TrEMBL-Plants: tr|K7LB25|K7LB25_SOYBN Molybdenum cofactor sulfurase; Found in the gene: LotjaGi3g1v0054500 | 18 | ||
| – | Molybdenum cofactor sulfurase family protein; TAIR: AT1G30910.1 Molybdenum cofactor sulfurase family protein; Swiss-Prot: sp|Q5VT66|MARC1_HUMAN Mitochondrial amidoxime-reducing component 1; TrEMBL-Plants: tr|I3SXQ0|I3SXQ0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0244900 | 11 | ||
| – | Molybdenum cofactor sulfurase family protein; TAIR: AT1G30910.1 Molybdenum cofactor sulfurase family protein; Swiss-Prot: sp|O88994|MARC2_RAT Mitochondrial amidoxime reducing component 2; TrEMBL-Plants: tr|I3SXQ0|I3SXQ0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0245000 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SignalP-TM | SignalP_GRAM_NEGATIVE | 1 | 12.50 |