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IPR006066 is a Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site.
<p>Nitrite reductases and bacterial sulphite reductases catalyse the 6-electron reduction of nitrite (sulphite) to ammonia (sulphide) [[cite:PUB00005356]]. On the basis of physiological function, 2 types of nitrite reductase can be defined: the assimilatory type, which is involved in nitrate assimilation (denitrification); and the dissimilatory type, which is responsible for nitrate respiration function. Assimilatory nitrite reductases contain a prosthetic group termed sirohaem (an iron tetra-hydroporphyrin of the isobacteriochlorin type, with 8 carboxylic acid-containing peripheral sidechains), and an iron-sulphur cluster. Similarly, there are 2 types of sulphite reductase: the assimilatory type, which participate in the synthesis of sulphur-containing compounds; and the dissimilatory type, which are terminal reductases in the reduction of sulphate. Assimilatory sulphite reductases can catalyse 6-electron reduction without the formation of free intermediates, while dissimilatory reductases can produce trithionate and thiosulphate in addition to sulphide. Both types of reductase contain sirohaem and iron-sulphur clusters. A region of sequence similarity, about 80 amino acids long, is shared by assimilatory nitrite [[cite:PUB00005356]] and sulphite reductases [[cite:PUB00002132], [cite:PUB00002508]]. Four conserved Cys residues are suggested to be involved in binding the sirohaem group and/or the iron-sulphur centre [[cite:PUB00002508]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. | ||
| Molecular function | Heme binding | Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. | ||
| Molecular function | Iron-sulfur cluster binding | Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: sulfite reductase [ferredoxin] gi|356538473|ref|XP_003537728.1| | 15 | ||
| – | Ferredoxin-nitrite reductase [Lotus japonicus] gi|9968473|emb|CAC06095.1| | 14 | ||
| – | Ferredoxin-nitrite reductase [Lotus japonicus] gi|9968473|emb|CAC06095.1| | 13 | ||
| – | Ferredoxin-nitrite reductase [Lotus japonicus] gi|9968473|emb|CAC06095.1| | 13 | ||
| – | Sulfite reductase [NADPH] hemoprotein beta-component; TAIR: AT5G04590.1 sulfite reductase; Swiss-Prot: sp|Q75NZ0|SIR_PEA Sulfite reductase [ferredoxin], chloroplastic; TrEMBL-Plants: tr|A0A0B2P8I5|A0A0B2P8I5_GLYSO Sulfite reductase [ferredoxin]; Found in the gene: LotjaGi3g1v0537300 | 16 | ||
| – | Sulfite reductase [NADPH] hemoprotein beta-component; TAIR: AT5G04590.1 sulfite reductase; Swiss-Prot: sp|Q75NZ0|SIR_PEA Sulfite reductase [ferredoxin], chloroplastic; TrEMBL-Plants: tr|A0A0B2P8I5|A0A0B2P8I5_GLYSO Sulfite reductase [ferredoxin]; Found in the gene: LotjaGi3g1v0537300 | 17 | ||
| – | Nitrite reductase; TAIR: AT2G15620.1 nitrite reductase 1; Swiss-Prot: sp|P38500|NIR_BETPN Ferredoxin--nitrite reductase, chloroplastic; TrEMBL-Plants: tr|Q9FY16|Q9FY16_LOTJA Ferredoxin-nitrite reductase; Found in the gene: LotjaGi4g1v0074400 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SignalP-TM | SignalP_GRAM_NEGATIVE | 1 | 14.29 |