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IPR006067

Description

IPR006067 is a Nitrite/sulphite reductase 4Fe-4S domain.

<p>Sulphite reductases (SiRs) and related nitrite reductases (NiRs) catalyse the six-electron reduction reactions of sulphite to sulphide, and nitrite to ammonia, respectively. The Escherichia coli SiR enzyme is a complex composed of two proteins, a flavoprotein alpha-component (SiR-FP) and a hemoprotein beta-component (SiR-HP) ([interpro:IPR005117]), and has an α(8)β(4) quaternary structure [[cite:PUB00014351]]. SiR-FP contains both FAD and FMN, while SiR-HP contains a Fe(4)S(4) cluster coupled to a siroheme through a cysteine bridge. Electrons are transferred from NADPH to FAD, and on to FMN in SiR-FP, from which they are transferred to the metal centre of SiR-HP, where they reduce the siroheme-bound sulphite.</p> <p>SiR-HP has a two-fold symmetry, which generates a distinctive three-domain α/β fold that controls assembly and reactivity [[cite:PUB00014496]]. In the E. coli SiR-HP enzyme ([ec:1.8.1.2]), the iron is bound to cysteine residues at positions 433, 439, 478 and 482, the latter also forming the siroheme ligand.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Molecular function Oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
Molecular function Heme binding Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
Molecular function Iron-sulfur cluster binding Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms.
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.

Associated Lotus transcripts 7

Transcript Name Description Predicted domains Domain count
PREDICTED: sulfite reductase [ferredoxin] gi|356538473|ref|XP_003537728.1| 15
Ferredoxin-nitrite reductase [Lotus japonicus] gi|9968473|emb|CAC06095.1| 14
Ferredoxin-nitrite reductase [Lotus japonicus] gi|9968473|emb|CAC06095.1| 13
Ferredoxin-nitrite reductase [Lotus japonicus] gi|9968473|emb|CAC06095.1| 13
Sulfite reductase [NADPH] hemoprotein beta-component; TAIR: AT5G04590.1 sulfite reductase; Swiss-Prot: sp|Q75NZ0|SIR_PEA Sulfite reductase [ferredoxin], chloroplastic; TrEMBL-Plants: tr|A0A0B2P8I5|A0A0B2P8I5_GLYSO Sulfite reductase [ferredoxin]; Found in the gene: LotjaGi3g1v0537300 16
Sulfite reductase [NADPH] hemoprotein beta-component; TAIR: AT5G04590.1 sulfite reductase; Swiss-Prot: sp|Q75NZ0|SIR_PEA Sulfite reductase [ferredoxin], chloroplastic; TrEMBL-Plants: tr|A0A0B2P8I5|A0A0B2P8I5_GLYSO Sulfite reductase [ferredoxin]; Found in the gene: LotjaGi3g1v0537300 17
Nitrite reductase; TAIR: AT2G15620.1 nitrite reductase 1; Swiss-Prot: sp|P38500|NIR_BETPN Ferredoxin--nitrite reductase, chloroplastic; TrEMBL-Plants: tr|Q9FY16|Q9FY16_LOTJA Ferredoxin-nitrite reductase; Found in the gene: LotjaGi4g1v0074400 15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SignalP-TM SignalP_GRAM_NEGATIVE 1 14.29