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IPR006138

Source: InterPro

Description

IPR006138 is a NADH-ubiquinone oxidoreductase, 20 Kd subunit.

<p>NADH:ubiquinone oxidoreductase (complex I) ([ec:7.1.1.2]) is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) [[cite:PUB00005074]]. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [[cite:PUB00043561]], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins [[cite:PUB00045437]].</p> <p>Among the many polypeptide subunits that make up complex I, there is one with a molecular weight of 20kDa (in mammals) [[cite:PUB00001635]], which is a component of the iron-sulphur (IP) fragment of the enzyme. It seems to bind a 4Fe-4S iron-sulphur cluster. The 20kDa subunit has been found to be nuclear encoded, as a precursor form with a transit peptide in mammals, and in Neurospora crassa. It is mitochondrial encoded in Paramecium (gene psbG) and chloroplast encoded in various higher plants (gene ndhK or psbG).</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0008137
Molecular function NADH dehydrogenase (ubiquinone) activity Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol.
Subterm of
GO:0048038
Molecular function Quinone binding Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds.
Subterm of
GO:0051539
Molecular function 4 iron, 4 sulfur cluster binding Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
Subterm of
GO:0055114
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
Subterm of

Associated Lotus transcripts 7

Transcript Name Description Predicted domains Domain count
Lj0g3v0124989.1
– Ribosomal protein S11 [Lotus japonicus] gi|13518471|ref|NP_084830.1|
Domains
12
Lj1g3v1785880.1
– NADH-ubiquinone oxidoreductase subunit-like protein [Medicago truncatula] gi|357465715|ref|XP_003603142.1|
Domains
18
Lj1g3v1785880.2
– PREDICTED: NADH dehydrogenase [ubiquinone] gi|225429464|ref|XP_002277483.1|
Domains
12
Ljchlorog3v0000080.1
– NADH dehydrogenase subunit K [Lotus japonicus] gi|13518424|ref|NP_084784.1|
Domains
10
LotjaGi1g1v0366400.1
– NADH-quinone oxidoreductase subunit B; TAIR: AT5G11770.1 NADH-ubiquinone oxidoreductase 20 kDa subunit; Swiss-Prot: sp|P42027|NDUS7_BRAOL NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; TrEMBL-Plants: tr|F6H393|F6H393_VITVI Putative uncharacterized protein; Found in the gene: LotjaGi1g1v0366400
Domains
12
LotjaGi1g1v0366400.2
– NADH-quinone oxidoreductase subunit B; TAIR: AT5G11770.1 NADH-ubiquinone oxidoreductase 20 kDa subunit; Swiss-Prot: sp|P42027|NDUS7_BRAOL NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; TrEMBL-Plants: tr|F6H393|F6H393_VITVI Putative uncharacterized protein; Found in the gene: LotjaGi1g1v0366400
Domains
12
LotjaGi6g1v0000600_LC.1
– NAD(P)H-quinone oxidoreductase subunit K, chloroplastic; TAIR: ATCG00430.1 photosystem II reaction center protein G (ChrC); Swiss-Prot: sp|Q9BBT7|NDHK_LOTJA NAD(P)H-quinone oxidoreductase subunit K, chloroplastic; TrEMBL-Plants: tr|I3SJ79|I3SJ79_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0000600_LC
Domains
8

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF56770 SUPERFAMILY 1 14.29