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IPR006157 is a Dihydroneopterin aldolase/epimerase domain.
<p>Dihydroneopterin aldolase (DHNA or folB) catalyses the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate [[cite:PUB00081682]]. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate and DHNA is one enzyme in this pathway. In the opportunistic pathogen Pneumocystis carinii, dihydroneopterin aldolase function is expressed as the N-terminal portion of the multifunctional folic acid synthesis protein (Fas). This region encompasses two domains, FasA and FasB, which are 27% amino acid identical [[cite:PUB00010575]]. FasA and FasB also share significant amino acid sequence similarity with bacterial dihydroneopterin aldolases.</p> <p>This entry also includes 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE or folX). Though it is known that DHNTPE catalyzes the epimerization of dihydroneopterin triphosphate to dihydromonapterin triphosphate, the biological role of this enzyme is still unclear. It is hypothesized that it is not an essential protein since a folX knockout in E. coli has a normal phenotype and the fact that folX is not present in H. influenza [[cite:PUB00081680], [cite:PUB00081681]]. DHNA and DHNTPE have been shown to be able to compensate for the other's activity albeit at slower reaction rates [[cite:PUB00007944]]. The functional enzyme for both is an octamer of identical subunits. Mammals lack many of the enzymes in the folate pathway including, DHNA and DHNTPE.</p> <p>This region consists of two tandem sequences each homologous to folB and which form tetramers [[cite:PUB00081683]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Dihydroneopterin aldolase activity | Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde. | ||
| Biological process | Folic acid-containing compound metabolic process | The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Dihydroneopterin aldolase [Phaseolus vulgaris] gi|319428656|gb|ADV56680.1| | 11 | ||
| – | Dihydroneopterin aldolase [Phaseolus vulgaris] gi|319428656|gb|ADV56680.1| | 17 | ||
| – | Dihydroneopterin aldolase [Phaseolus vulgaris] gi|319428656|gb|ADV56680.1| | 17 | ||
| – | Dihydroneopterin aldolase [Medicago truncatula] gi|357453481|ref|XP_003597018.1| | 17 | ||
| – | 7,8-dihydroneopterin aldolase; TAIR: AT3G11750.1 Dihydroneopterin aldolase; Swiss-Prot: sp|Q9SF23|FOLB1_ARATH Dihydroneopterin aldolase 1; TrEMBL-Plants: tr|I3S513|I3S513_LOTJA 7,8-dihydroneopterin aldolase; Found in the gene: LotjaGi1g1v0739400 | 12 | ||
| – | 7,8-dihydroneopterin aldolase; TAIR: AT3G11750.1 Dihydroneopterin aldolase; Swiss-Prot: sp|Q9SF23|FOLB1_ARATH Dihydroneopterin aldolase 1; TrEMBL-Plants: tr|I3SSH4|I3SSH4_LOTJA 7,8-dihydroneopterin aldolase; Found in the gene: LotjaGi6g1v0152300_LC | 19 | ||
| – | 7,8-dihydroneopterin aldolase; TAIR: AT3G11750.1 Dihydroneopterin aldolase; Swiss-Prot: sp|Q9SF23|FOLB1_ARATH Dihydroneopterin aldolase 1; TrEMBL-Plants: tr|I3SQ87|I3SQ87_LOTJA 7,8-dihydroneopterin aldolase; Found in the gene: LotjaGi6g1v0152400_LC | 18 | ||
| – | 7,8-dihydroneopterin aldolase; TAIR: AT3G11750.1 Dihydroneopterin aldolase; Swiss-Prot: sp|Q9SF23|FOLB1_ARATH Dihydroneopterin aldolase 1; TrEMBL-Plants: tr|I3SSH4|I3SSH4_LOTJA 7,8-dihydroneopterin aldolase; Found in the gene: LotjaGi6g1v0152400_LC | 18 | ||
| – | 7,8-dihydroneopterin aldolase; TAIR: AT3G11750.1 Dihydroneopterin aldolase; Swiss-Prot: sp|Q9SF23|FOLB1_ARATH Dihydroneopterin aldolase 1; TrEMBL-Plants: tr|I3SC22|I3SC22_LOTJA 7,8-dihydroneopterin aldolase; Found in the gene: LotjaGi6g1v0152500 | 19 | ||
| – | 7,8-dihydroneopterin aldolase; TAIR: AT3G11750.1 Dihydroneopterin aldolase; Swiss-Prot: sp|Q9SF23|FOLB1_ARATH Dihydroneopterin aldolase 1; TrEMBL-Plants: tr|I3SC22|I3SC22_LOTJA 7,8-dihydroneopterin aldolase; Found in the gene: LotjaGi6g1v0152500 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00534 | CDD | 1 | 10.00 |