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IPR006274

Source: InterPro

Description

IPR006274 is a Carbamoyl-phosphate synthase, small subunit.

<p>Carbamoyl phosphate synthase (CPSase) is a heterodimeric enzyme composed of a small and a large subunit (with the exception of CPSase III, see below). CPSase catalyses the synthesis of carbamoyl phosphate from biocarbonate, ATP and glutamine or ammonia, and represents the first committed step in pyrimidine and arginine biosynthesis in prokaryotes and eukaryotes, and in the urea cycle in most terrestrial vertebrates [[cite:PUB00006448], [cite:PUB00042597]]. This entry represents the small subunit of the glutamine-dependent form ([ec:6.3.5.5]) of carbamoyl phosphate synthase. The small subunit catalyses the hydrolysis of glutamine to ammonia, which in turn used by the large chain to synthesize carbamoyl phosphate. The C-terminal domain of the small subunit of CPSase has glutamine amidotransferase activity.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004088
Molecular function Carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.
Subterm of
GO:0006207
Biological process 'de novo' pyrimidine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.
Subterm of
GO:0006541
Biological process Glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj1g3v1276960.2
– Carbamoyl-phosphate synthase small chain [Medicago truncatula] gi|357477159|ref|XP_003608865.1|
Domains
19
LotjaGi1g1v0315900.1
– Carbamoyl-phosphate synthase small chain; TAIR: AT3G27740.1 carbamoyl phosphate synthetase A; Swiss-Prot: sp|Q9LVW7|CARA_ARATH Carbamoyl-phosphate synthase small chain, chloroplastic; TrEMBL-Plants: tr|I3SBA2|I3SBA2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0315900
Domains
22

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd01744 CDD 1 50.00