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IPR006312 is a Sec-independent protein translocase protein TatA/E.
<p>Translocation of proteins across the two membranes of Gram-negative bacteria can be carried out via a number of routes. Most proteins marked for export carry a secretion signal at their N terminus, and are secreted by the general secretory pathway. The signal peptide is cleaved as they pass through the outer membrane. Other secretion systems include the type III system found in a select group of Gram-negative plant and animal pathogens, and the CagA system of Helicobacter pylori [[cite:PUB00007662]].</p> <p>In some bacterial species, however, there exists a system that operates independently of the Sec pathway [[cite:PUB00007663]]. It selectively translocates periplasmic-bound molecules that are synthesised with, or are in close association with, "partner" proteins bearing an (S/T)RRXFLK twin arginine motif at the N terminus. The pathway is therefore termed the Twin-Arginine Translocation or TAT system. Surprisingly, the four components that make up the TAT system are structurally and mechanistically related to a pH-dependent import system in plant chloroplast thylakoid membranes [[cite:PUB00007663]]. The gene products responsible for the Sec-independent pathway are called TatA, TatB, TatC and TatE.</p> <p>TatA and TatE are highly related proteins and appear to overlap in functionality [[cite:PUB00007662]]. Translocation occurred in single mutants of either TatA or TatE, though much less efficiently, but double mutants showed no detectable translocation.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. | ||
| Biological process | Protein transport by the Tat complex | The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: sec-independent protein translocase protein TATA, chloroplastic-like [Cicer arietinum] gi|502113595|ref|XP_004494699.1| | 19 | ||
| – | PREDICTED: sec-independent protein translocase protein TATB, chloroplastic-like [Cicer arietinum] gi|502119210|ref|XP_004496540.1| | 12 | ||
| – | Sec-independent protein translocase protein TatA; TAIR: AT5G28750.1 Bacterial sec-independent translocation protein mttA/Hcf106; Swiss-Prot: sp|Q9XH46|TATA_PEA Sec-independent protein translocase protein TATA, chloroplastic; TrEMBL-Plants: tr|I3T5R6|I3T5R6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0781600 | 17 | ||
| – | Sec-independent protein translocase protein TatA; TAIR: AT5G52440.1 Bacterial sec-independent translocation protein mttA/Hcf106; Swiss-Prot: sp|Q94G16|TATB_PEA Sec-independent protein translocase protein TATB, chloroplastic; TrEMBL-Plants: tr|I3S6U9|I3S6U9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0298200 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |