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IPR006342 is a Methyltransferase FkbM.
<p>This domain is characterised by two well-conserved short regions separated by a variable region in both sequence and length. The first of the two regions is found in a large number of proteins outside this group, a number of which have been characterised as methyltransferases. One member of this group, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548 [[cite:PUB00009583]].</p> <p>This domain is also found in other methyltransferases such as SdnD from the fungus Sordaria araneosa, involved in the biosynthesis of glycoside antibiotics with tetracyclic diterpene aglycone structure [[cite:PUB00089798]] and in AMB antimetabolite synthase AmbE from Pseudomonas aeruginosa, which participates in the biosynthesis of the antimetabolite L-2-amino-4-methoxy-trans-3-butenoic acid (AMB), a non-proteinogenic amino acid which is toxic for prokaryotes and eukaryotes [[cite:PUB00100396], [cite:PUB00100397]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Methyltransferases [Theobroma cacao] gi|508715155|gb|EOY07052.1| | 13 | ||
| – | Nodulation protein noeI [Theobroma cacao] gi|508783803|gb|EOY31059.1| | 8 | ||
| – | Methyltransferase; TAIR: AT5G01710.1 methyltransferase; Swiss-Prot: sp|A5FZN7|BIOD_ACICJ ATP-dependent dethiobiotin synthetase BioD; TrEMBL-Plants: tr|V7B2Z1|V7B2Z1_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0448400 | 13 | ||
| – | Methyltransferase; TAIR: AT5G01710.1 methyltransferase; Swiss-Prot: sp|Q88SI6|MENG_LACPL Demethylmenaquinone methyltransferase; TrEMBL-Plants: tr|V7ALZ9|V7ALZ9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0201400 | 13 | ||
| – | Family methyltransferase; TAIR: AT2G26680.1 FkbM family methyltransferase; Swiss-Prot: sp|D4GYG5|AGLP_HALVD Hexuronic acid methyltransferase AglP; TrEMBL-Plants: tr|G7JCY4|G7JCY4_MEDTR FkbM family methyltransferase; Found in the gene: LotjaGi4g1v0270500 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TMhelix | TMHMM | 1 | 20.00 |