Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR006415

Description

IPR006415 is a P-type ATPase, subfamily IIIB.

<p>Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP.</p> <p>P-ATPases (also known as E1-E2 ATPases) ([ec:7.2.2.6]) are found in bacteria and in a number of eukaryotic plasma membranes and organelles [[cite:PUB00009616]]. P-ATPases function to transport a variety of different compounds, including ions and phospholipids, across a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases, which transport specific types of ion: H<sup>+</sup>, Na<sup>+</sup>, K<sup>+</sup>, Mg<sup>2+</sup>, Ca<sup>2+</sup>, Ag<sup>+</sup>and Ag<sup>2+</sup>, Zn<sup>2+</sup>, Co<sup>2+</sup>, Pb<sup>2+</sup>, Ni<sup>2+</sup>, Cd<sup>2+</sup>, Cu<sup>+</sup>and Cu<sup>2+</sup> [[cite:PUB00160066], [cite:PUB00160065]]. P-ATPases can be composed of one or two polypeptides, and can usually assume two main conformations called E1 and E2.</p> <p>This group describes the magnesium translocating P-type ATPase found in a limited number of bacterial species and best described in Salmonella typhimurium, which contains two isoforms [[cite:PUB00009627]]. These transporters are active in low external Mg2+ concentrations and pump the ion into the cytoplasm. The magnesium ATPases have been classified as type IIIB by a phylogenetic analysis [[cite:PUB00009616]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Molecular function Magnesium-importing ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) -> ADP + phosphate + Mg2+(in).
Biological process Magnesium ion transport The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Cellular component Integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Associated Lotus transcripts 7

Transcript Name Description Predicted domains Domain count
PREDICTED: magnesium-transporting ATPase, P-type 1-like isoform X1 [Cicer arietinum] gi|502140214|ref|XP_004504112.1| 28
Plasma membrane ATPase; TAIR: AT1G10130.1 endoplasmic reticulum-type calcium-transporting ATPase 3; Swiss-Prot: sp|P22036|ATMB_SALTY Magnesium-transporting ATPase, P-type 1; TrEMBL-Plants: tr|A0A0R0JX21|A0A0R0JX21_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0393900 32
Plasma membrane ATPase; TAIR: AT1G10130.1 endoplasmic reticulum-type calcium-transporting ATPase 3; Swiss-Prot: sp|P22036|ATMB_SALTY Magnesium-transporting ATPase, P-type 1; TrEMBL-Plants: tr|A0A0R0JX32|A0A0R0JX32_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0393900 32
Plasma membrane ATPase; TAIR: AT1G10130.1 endoplasmic reticulum-type calcium-transporting ATPase 3; Swiss-Prot: sp|P22036|ATMB_SALTY Magnesium-transporting ATPase, P-type 1; TrEMBL-Plants: tr|A0A0R0JX32|A0A0R0JX32_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0393900 32
Plasma membrane ATPase; TAIR: AT1G10130.1 endoplasmic reticulum-type calcium-transporting ATPase 3; Swiss-Prot: sp|P22036|ATMB_SALTY Magnesium-transporting ATPase, P-type 1; TrEMBL-Plants: tr|A0A0R0JX32|A0A0R0JX32_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0393900 32
Plasma membrane ATPase; TAIR: AT1G10130.1 endoplasmic reticulum-type calcium-transporting ATPase 3; Swiss-Prot: sp|P22036|ATMB_SALTY Magnesium-transporting ATPase, P-type 1; TrEMBL-Plants: tr|A0A0B2PFZ4|A0A0B2PFZ4_GLYSO Magnesium-transporting ATPase, P-type 1; Found in the gene: LotjaGi4g1v0393900 32
Plasma membrane ATPase; TAIR: AT1G10130.1 endoplasmic reticulum-type calcium-transporting ATPase 3; Swiss-Prot: sp|P22036|ATMB_SALTY Magnesium-transporting ATPase, P-type 1; TrEMBL-Plants: tr|A0A0B2PFZ4|A0A0B2PFZ4_GLYSO Magnesium-transporting ATPase, P-type 1; Found in the gene: LotjaGi4g1v0393900 31

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 14.29