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IPR006598 is a Glycosyl transferase CAP10 domain.
<p>The CAP10 domain is found in glycosyltransferases from animals, plants and fungi. Rumi is a Drosophila protein with a CAP10 domain that functions as a protein O-glucosyltransferase. In human and mouse, three potential homologues exist: one with a high degree of identity to Drosophila Rumi (52%), and two others with lower degrees of identity but including a CAP10 domain (KDELC1 and KDELC2) [[cite:PUB00091688]]. Rumi catalyzes the transfer of glucose and/or xylose from UDP-glucose and UDP-xylose, respectively, to a serine within the consensus Cys-Xaa-Ser-Xaa-Pro-Cys) in epidermal growth factor repeats, such as those found in coagulation factors F7, F9 and NOTCH proteins. Notch signaling is regulated by Notch glucosylation and glucosylation is required for the correct folding and cleavage of Notch [[cite:PUB00078836], [cite:PUB00078837]].</p> <p>CAP10 from Cryptococcus neoformans encodes a xylosyltransferase [[cite:PUB00091691]]. This pathogenic fungus, which most commonly affects the central nervous system and causes fatal meningoencephalitis primarily in patients with AIDS, produces a thick extracellular polysaccharide capsule which is well recognised as a virulence factor. The CAP10 domain is required for capsule formation and virulence [[cite:PUB00009687]]. The capsule is primarily made of two xylose-containing polysaccharides, glucuronoxylomannan and galactoxylomannan, and the glycosyltransferase transfers xylose to alpha-1,3-dimannoside in a beta-1,2-linkage [[cite:PUB00078838]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: protein O-glucosyltransferase 1-like [Glycine max] gi|356504647|ref|XP_003521107.1| | 6 | ||
| – | PREDICTED: O-glucosyltransferase rumi-like [Glycine max] gi|356569533|ref|XP_003552954.1| | 9 | ||
| – | KTEL motif-containing protein [Medicago truncatula] gi|357497409|ref|XP_003618993.1| | 11 | ||
| – | PREDICTED: O-glucosyltransferase rumi homolog isoform X1 [Cicer arietinum] gi|502167252|ref|XP_004514091.1| | 6 | ||
| – | KTEL motif-containing protein [Medicago truncatula] gi|357497409|ref|XP_003618993.1| | 4 | ||
| – | PREDICTED: O-glucosyltransferase rumi homolog isoform X1 [Cicer arietinum] gi|502167252|ref|XP_004514091.1| | 9 | ||
| – | PREDICTED: KDEL motif-containing protein 1-like [Glycine max] gi|356497228|ref|XP_003517464.1| | 11 | ||
| – | PREDICTED: protein O-glucosyltransferase 1-like [Glycine max] gi|356504647|ref|XP_003521107.1| | 6 | ||
| – | PREDICTED: O-glucosyltransferase rumi-like [Glycine max] gi|356541729|ref|XP_003539326.1| | 5 | ||
| – | O-glucosyltransferase rumi like; TAIR: AT3G48980.2 O-glucosyltransferase rumi-like protein (DUF821); Swiss-Prot: sp|B0X1Q4|RUMI_CULQU O-glucosyltransferase rumi homolog; TrEMBL-Plants: tr|A0A151TBL3|A0A151TBL3_CAJCA KDEL motif-containing protein 1; Found in the gene: LotjaGi1g1v0473600 | 10 | ||
| – | O-glucosyltransferase rumi like; TAIR: AT5G23850.1 O-glucosyltransferase rumi-like protein (DUF821); Swiss-Prot: sp|B0X1Q4|RUMI_CULQU O-glucosyltransferase rumi homolog; TrEMBL-Plants: tr|A0A172J2D1|A0A172J2D1_PUEML UDP-glycosyltransferase 47; Found in the gene: LotjaGi2g1v0142700 | 9 | ||
| – | O-glucosyltransferase rumi like; TAIR: AT5G23850.1 O-glucosyltransferase rumi-like protein (DUF821); Swiss-Prot: sp|B0X1Q4|RUMI_CULQU O-glucosyltransferase rumi homolog; TrEMBL-Plants: tr|A0A172J2D1|A0A172J2D1_PUEML UDP-glycosyltransferase 47; Found in the gene: LotjaGi2g1v0142700 | 9 | ||
| – | O-glucosyltransferase rumi like; TAIR: AT5G23850.1 O-glucosyltransferase rumi-like protein (DUF821); Swiss-Prot: sp|B0X1Q4|RUMI_CULQU O-glucosyltransferase rumi homolog; TrEMBL-Plants: tr|A0A072TJX6|A0A072TJX6_MEDTR Glycosyltransferase family 90 protein; Found in the gene: LotjaGi2g1v0143000 | 5 | ||
| – | O-glucosyltransferase rumi-like protein; TAIR: AT5G23850.1 O-glucosyltransferase rumi-like protein (DUF821); Swiss-Prot: sp|B0X1Q4|RUMI_CULQU O-glucosyltransferase rumi homolog; TrEMBL-Plants: tr|I1JA60|I1JA60_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0432900 | 11 | ||
| – | O-glucosyltransferase rumi-like protein; TAIR: AT2G45830.1 downstream target of AGL15 2; Swiss-Prot: sp|Q8NBL1|PGLT1_HUMAN Protein O-glucosyltransferase 1; TrEMBL-Plants: tr|A0A072TN56|A0A072TN56_MEDTR Glycosyltransferase family 90 protein; Found in the gene: LotjaGi3g1v0380900 | 11 | ||
| – | O-glucosyltransferase rumi like; TAIR: AT5G23850.1 O-glucosyltransferase rumi-like protein (DUF821); Swiss-Prot: sp|B0X1Q4|RUMI_CULQU O-glucosyltransferase rumi homolog; TrEMBL-Plants: tr|K7L076|K7L076_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0381300 | 12 | ||
| – | O-glucosyltransferase rumi; TAIR: AT1G07220.1 O-glucosyltransferase rumi-like protein (DUF821); Swiss-Prot: sp|Q8T045|RUMI_DROME O-glucosyltransferase rumi; TrEMBL-Plants: tr|I1MZZ5|I1MZZ5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0113300 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 5.88 |