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IPR006700 is a Ribosomal RNA small subunit methyltransferase E.
<p>Methyltransferases (Mtases) are responsible for the transfer of methyl groups between two molecules. The transfer of the methyl group from the ubiquitous S-adenosyl-L-methionine (AdoMet) to either nitrogen, oxygen or carbon atoms is frequently employed in diverse organisms. The reaction is catalysed by Mtases and modifies DNA, RNA, proteins or small molecules, such as catechol, for regulatory purposes. Proteins in this entry belong to the RsmE family of Mtases, this is supported by crystal structural studies, which show a close structural homology to other known methyltransferases [[cite:PUB00029267]].</p> <p>This group of proteins includes Ribosomal RNA small subunit methyltransferase E (RsmE) from Escherichia coli, which specifically methylates the uridine in position 1498 of 16S rRNA in the fully assembled 30S ribosomal subunit [[cite:PUB00044729], [cite:PUB00044730]]. This enzyme has two distinct but structurally related domains: the N-terminal PUA domain and the conserved MTase domain at the C-terminal end. This protein adopts a dimeric configuration that is functionally critical for substrate binding and catalysis [[cite:PUB00062463]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | RRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. | ||
| Molecular function | Methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ribosomal RNA small subunit methyltransferase E-like [Cicer arietinum] gi|502120160|ref|XP_004496867.1| | 8 | ||
| – | PREDICTED: ribosomal RNA small subunit methyltransferase E-like [Cicer arietinum] gi|502120160|ref|XP_004496867.1| | 11 | ||
| – | Ribosomal RNA small subunit methyltransferase E; TAIR: AT1G50000.1 methyltransferase; Swiss-Prot: sp|O66552|RSME_AQUAE Ribosomal RNA small subunit methyltransferase E; TrEMBL-Plants: tr|A0A0S3SM93|A0A0S3SM93_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0174700 | 12 | ||
| – | Ribosomal RNA small subunit methyltransferase E; TAIR: AT1G50000.1 methyltransferase; Swiss-Prot: sp|O66552|RSME_AQUAE Ribosomal RNA small subunit methyltransferase E; TrEMBL-Plants: tr|A0A072VQR6|A0A072VQR6_MEDTR Ribosomal RNA small subunit methyltransferase E; Found in the gene: LotjaGi1g1v0174700 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd18084 | CDD | 1 | 25.00 |