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IPR007371 is a Thiamin pyrophosphokinase, catalytic domain.
<p>Thiamin pyrophosphokinase (TPK, [ec:2.7.6.2]) catalyzes the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggests that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis [[cite:PUB00009922]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Thiamine diphosphokinase activity | Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate. | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | Thiamine diphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: thiamin pyrophosphokinase 1-like [Glycine max] gi|356505566|ref|XP_003521561.1| | 5 | ||
| – | PREDICTED: thiamin pyrophosphokinase 1-like [Glycine max] gi|356505566|ref|XP_003521561.1| | 8 | ||
| – | PREDICTED: thiamin pyrophosphokinase 1-like [Glycine max] gi|356505566|ref|XP_003521561.1| | 6 | ||
| – | PREDICTED: thiamin pyrophosphokinase 1-like [Cicer arietinum] gi|502112556|ref|XP_004494369.1| | 14 | ||
| – | PREDICTED: thiamin pyrophosphokinase 1-like [Glycine max] gi|356505566|ref|XP_003521561.1| | 17 | ||
| – | ATP-dependent DNA helicase PIF1 [Medicago truncatula] gi|357521729|ref|XP_003631153.1| | 5 | ||
| – | Thiamin pyrophosphokinase 1; TAIR: AT1G02880.3 thiamin pyrophosphokinase1; Swiss-Prot: sp|B9DGU7|TPK1_ARATH Thiamine pyrophosphokinase 1; TrEMBL-Plants: tr|K7KGB3|K7KGB3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0489200 | 18 | ||
| – | Thiamin pyrophosphokinase 1; TAIR: AT1G02880.2 thiamin pyrophosphokinase1; Swiss-Prot: sp|B9DGU7|TPK1_ARATH Thiamine pyrophosphokinase 1; TrEMBL-Plants: tr|K7KGB3|K7KGB3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0489200 | 17 | ||
| – | Thiamin pyrophosphokinase 1; TAIR: AT1G02880.2 thiamin pyrophosphokinase1; Swiss-Prot: sp|B9DGU7|TPK1_ARATH Thiamine pyrophosphokinase 1; TrEMBL-Plants: tr|K7KGB3|K7KGB3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0489200 | 17 | ||
| – | Thiamin pyrophosphokinase 1; TAIR: AT1G02880.1 thiamin pyrophosphokinase1; Swiss-Prot: sp|B9DGU7|TPK1_ARATH Thiamine pyrophosphokinase 1; TrEMBL-Plants: tr|I3SYQ3|I3SYQ3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0489200 | 17 | ||
| – | Thiamin pyrophosphokinase 1; TAIR: AT2G44750.2 thiamin pyrophosphokinase 2; Swiss-Prot: sp|F4IV16|TPK2_ARATH Thiamine pyrophosphokinase 2; TrEMBL-Plants: tr|K7KGB3|K7KGB3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0766000 | 18 | ||
| – | Thiamin pyrophosphokinase 1; TAIR: AT2G44750.2 thiamin pyrophosphokinase 2; Swiss-Prot: sp|F4IV16|TPK2_ARATH Thiamine pyrophosphokinase 2; TrEMBL-Plants: tr|K7KGB3|K7KGB3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0766000 | 19 | ||
| – | Thiamin pyrophosphokinase 1; TAIR: AT1G02880.1 thiamin pyrophosphokinase1; Swiss-Prot: sp|B9DGU7|TPK1_ARATH Thiamine pyrophosphokinase 1; TrEMBL-Plants: tr|I3SYQ3|I3SYQ3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0766000 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07995 | CDD | 1 | 7.69 |