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IPR036371 is a Thiamin pyrophosphokinase, thiamin-binding domain superfamily.
<p>Thiamin pyrophosphokinase (TPK, [ec:2.7.6.2]) catalyzes the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis [[cite:PUB00009922]].</p> <p>TPK is a homodimer, and each subunit consists of two domains. One domain resembles a Rossman fold, while the other domain forms a β-sheet flattened sandwich structure containing a jelly-roll topology. The active site is located in a cleft at the dimer interface and is formed from residues from domains of both subunits. The thiamin binding site is primarily defined by the sandwich domain of one subunit and by a loop from the α-β domain of the other subunit [[cite:PUB00009922]]. This superfamily describes the jelly-roll sandwich domain.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Thiamine diphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Thiamin pyrophosphokinase 1; TAIR: AT1G02880.3 thiamin pyrophosphokinase1; Swiss-Prot: sp|B9DGU7|TPK1_ARATH Thiamine pyrophosphokinase 1; TrEMBL-Plants: tr|K7KGB3|K7KGB3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0489200 | 18 | ||
| – | Thiamin pyrophosphokinase 1; TAIR: AT1G02880.2 thiamin pyrophosphokinase1; Swiss-Prot: sp|B9DGU7|TPK1_ARATH Thiamine pyrophosphokinase 1; TrEMBL-Plants: tr|K7KGB3|K7KGB3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0489200 | 17 | ||
| – | Thiamin pyrophosphokinase 1; TAIR: AT1G02880.2 thiamin pyrophosphokinase1; Swiss-Prot: sp|B9DGU7|TPK1_ARATH Thiamine pyrophosphokinase 1; TrEMBL-Plants: tr|K7KGB3|K7KGB3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0489200 | 17 | ||
| – | Thiamin pyrophosphokinase 1; TAIR: AT1G02880.1 thiamin pyrophosphokinase1; Swiss-Prot: sp|B9DGU7|TPK1_ARATH Thiamine pyrophosphokinase 1; TrEMBL-Plants: tr|I3SYQ3|I3SYQ3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0489200 | 17 | ||
| – | Thiamin pyrophosphokinase 1; TAIR: AT2G44750.2 thiamin pyrophosphokinase 2; Swiss-Prot: sp|F4IV16|TPK2_ARATH Thiamine pyrophosphokinase 2; TrEMBL-Plants: tr|K7KGB3|K7KGB3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0766000 | 18 | ||
| – | Thiamin pyrophosphokinase 1; TAIR: AT2G44750.2 thiamin pyrophosphokinase 2; Swiss-Prot: sp|F4IV16|TPK2_ARATH Thiamine pyrophosphokinase 2; TrEMBL-Plants: tr|K7KGB3|K7KGB3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0766000 | 19 | ||
| – | Thiamin pyrophosphokinase 1; TAIR: AT1G02880.1 thiamin pyrophosphokinase1; Swiss-Prot: sp|B9DGU7|TPK1_ARATH Thiamine pyrophosphokinase 1; TrEMBL-Plants: tr|I3SYQ3|I3SYQ3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0766000 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07995 | CDD | 1 | 14.29 |