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IPR007855 is a RNA-dependent RNA polymerase, eukaryotic-type.
<p>This entry represents various eukaryotic RNA-dependent RNA polymerases (RDRP; [ec:2.7.7.48]), such as RCRP-1, RDRP-2 and RDRP-6. These enzymes are involved in the amplification of regulatory microRNAs during post-transcriptional gene silencing [[cite:PUB00016353]]; they are also required for transcriptional gene silencing. Double-stranded RNA has been shown to induce gene silencing in diverse eukaryotes and by a variety of pathways [[cite:PUB00035781]]. These enzymes also play a role in the RNA interference (RNAi) pathway, which is important for heterochromatin formation, accurate chromosome segregation, centromere cohesion and telomere function during mitosis and meiosis. RDRP enzymes are highly conserved in most eukaryotes, but are missing in archaea and bacteria. The core catalytic domain of RDRP enzymes is structurally similar to the beta' subunit of DNA-dependent RNA polymerases (DDRP), however the other domains of DDRP show no similarity to those of RDRP.</p> <p>This entry also includes QDE-1 from the filamentous fungus Neurospora. QDE-1 is both an RdRP and a DNA-dependent RNA polymerase (DdRP). It is able to synthesize RNA from both ssRNA and single-stranded DNA (ssDNA) [[cite:PUB00092792]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA-directed 5'-3' RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: RNA-dependent RNA polymerase 1-like [Glycine max] gi|356519367|ref|XP_003528344.1| | 4 | ||
| – | PREDICTED: RNA-dependent RNA polymerase 6-like [Glycine max] gi|356507732|ref|XP_003522618.1| | 4 | ||
| – | PREDICTED: RNA-dependent RNA polymerase 6-like [Glycine max] gi|356515444|ref|XP_003526410.1| | 8 | ||
| – | PREDICTED: probable RNA-dependent RNA polymerase 5-like [Cicer arietinum] gi|502164066|ref|XP_004513037.1| | 5 | ||
| – | PREDICTED: probable RNA-dependent RNA polymerase 5-like [Cicer arietinum] gi|502164066|ref|XP_004513037.1| | 5 | ||
| – | PREDICTED: probable RNA-dependent RNA polymerase 5-like [Cicer arietinum] gi|502164066|ref|XP_004513037.1| | 4 | ||
| – | PREDICTED: RNA-dependent RNA polymerase 1-like [Glycine max] gi|356499585|ref|XP_003518619.1| | 7 | ||
| – | PREDICTED: RNA-dependent RNA polymerase 2-like [Cicer arietinum] gi|502152277|ref|XP_004508850.1| | 11 | ||
| – | PREDICTED: RNA-dependent RNA polymerase 2-like [Cicer arietinum] gi|502152277|ref|XP_004508850.1| | 3 | ||
| – | RNA-dependent RNA polymerase; TAIR: AT3G49500.1 RNA-dependent RNA polymerase 6; Swiss-Prot: sp|Q9SG02|RDR6_ARATH RNA-dependent RNA polymerase 6; TrEMBL-Plants: tr|T1YXS9|T1YXS9_LOTJA RNA-dependent RNA polymerase; Found in the gene: LotjaGi1g1v0384200 | 7 | ||
| – | RNA-dependent RNA polymerase; TAIR: AT3G49500.1 RNA-dependent RNA polymerase 6; Swiss-Prot: sp|Q9SG02|RDR6_ARATH RNA-dependent RNA polymerase 6; TrEMBL-Plants: tr|T1YXS9|T1YXS9_LOTJA RNA-dependent RNA polymerase; Found in the gene: LotjaGi1g1v0384200 | 7 | ||
| – | RNA-dependent RNA polymerase; TAIR: AT1G14790.1 RNA-dependent RNA polymerase 1; Swiss-Prot: sp|Q9LQV2|RDR1_ARATH RNA-dependent RNA polymerase 1; TrEMBL-Plants: tr|A0A151S591|A0A151S591_CAJCA RNA-dependent RNA polymerase; Found in the gene: LotjaGi2g1v0000800 | 8 | ||
| – | RNA-dependent RNA polymerase; TAIR: AT1G14790.1 RNA-dependent RNA polymerase 1; Swiss-Prot: sp|Q9LQV2|RDR1_ARATH RNA-dependent RNA polymerase 1; TrEMBL-Plants: tr|K7K760|K7K760_SOYBN RNA-dependent RNA polymerase; Found in the gene: LotjaGi2g1v0001000 | 7 | ||
| – | RNA-dependent RNA polymerase; TAIR: AT1G14790.1 RNA-dependent RNA polymerase 1; Swiss-Prot: sp|Q9LQV2|RDR1_ARATH RNA-dependent RNA polymerase 1; TrEMBL-Plants: tr|K7K760|K7K760_SOYBN RNA-dependent RNA polymerase; Found in the gene: LotjaGi2g1v0001000 | 7 | ||
| – | RNA-dependent RNA polymerase; TAIR: AT2G19930.3 RNA-dependent RNA polymerase family protein; Swiss-Prot: sp|O82188|RDR5_ARATH Probable RNA-dependent RNA polymerase 5; TrEMBL-Plants: tr|A0A151R3T9|A0A151R3T9_CAJCA RNA-dependent RNA polymerase; Found in the gene: LotjaGi2g1v0223900 | 5 | ||
| – | RNA-dependent RNA polymerase; TAIR: AT4G11130.1 RNA-dependent RNA polymerase 2; Swiss-Prot: sp|O82504|RDR2_ARATH RNA-dependent RNA polymerase 2; TrEMBL-Plants: tr|G7JNT8|G7JNT8_MEDTR RNA-dependent RNA polymerase; Found in the gene: LotjaGi4g1v0239000 | 9 | ||
| – | RNA-dependent RNA polymerase; TAIR: AT4G11130.1 RNA-dependent RNA polymerase 2; Swiss-Prot: sp|O82504|RDR2_ARATH RNA-dependent RNA polymerase 2; TrEMBL-Plants: tr|G7JNT8|G7JNT8_MEDTR RNA-dependent RNA polymerase; Found in the gene: LotjaGi4g1v0239000 | 4 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR23079:SF5 | PANTHER | 1 | 5.88 |