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IPR008111 is a RNA-binding motif protein 8.
<p>RNA-binding motif protein 8 (RBM8), also termed binder of OVCA1-1 (BOV-1) or RNA-binding protein Y14, is one of the components of the exon-exon junction complex (EJC) [[cite:PUB00094479]]. It has two isoforms, RBM8A and RBM8B, both of which are identical except that RBM8B is 16 amino acids shorter at its N terminus [[cite:PUB00010370]]. Three-dimensional modelling of the RBM8 RRM domain indicates that the sequences fold into an RNA-binding domain, forming a hydrophobic core between a β-sheet and two helices. The human RBM8A protein is ubiquitously expressed; the protein is localised predominantly in the cell nucleus and diffused throughout the cytoplasm [[cite:PUB00010370]]. It preferentially associates with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. Evidence suggests the protein remains associated with spliced mRNAs as a tag to indicate the position of spliced introns. Human RBM8A protein specifically binds to MAGOH, the human homologue of Drosophila mago nashi, a protein required for normal germ plasm development in the Drosophila embryo [[cite:PUB00007285]]; a similar association occurs with the Drosophila RBM8 protein, Tsunagi [[cite:PUB00010398]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. | ||
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
| Cellular component | Cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | ||
| Biological process | RNA processing | Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: RNA-binding protein 8A-like [Glycine max] gi|356497345|ref|XP_003517521.1| | 13 | ||
| – | RNA-binding family protein; TAIR: AT1G51510.1 RNA-binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|B5DGI7|RBM8A_SALSA RNA-binding protein 8A; TrEMBL-Plants: tr|V7CI74|V7CI74_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0443800 | 15 | ||
| – | RNA-binding family protein; TAIR: AT1G51510.1 RNA-binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|B5DGI7|RBM8A_SALSA RNA-binding protein 8A; TrEMBL-Plants: tr|V7CI74|V7CI74_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0443800 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |