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IPR033744 is a RBM8, RNA recognition motif.
<p>This entry corresponds to the RNA recognition motif of RBM8. RNA-binding protein RBM8, also termed binder of OVCA1-1 (BOV-1) or RNA-binding protein Y14, is one of the components of the exon-exon junction complex (EJC) [[cite:PUB00094479]]. It has two isoforms, RBM8A and RBM8B, both of which are identical except that RBM8B is 16 amino acids shorter at its N terminus [[cite:PUB00010370]]. RBM8, together with other EJC components (such as Magoh, Aly/REF, RNPS1, Srm160, and Upf3), plays critical roles in postsplicing processing, including nuclear export and cytoplasmic localization of the mRNA, and the nonsense-mediated mRNA decay (NMD) surveillance process. RBM8 binds to mRNA 20-24 nucleotides upstream of a spliced exon-exon junction. It is also involved in spliced mRNA nuclear export, and the process of nonsense-mediated decay of mRNAs with premature stop codons. RBM8 forms a specific heterodimer complex with the EJC protein Magoh which then associates with Aly/REF, RNPS1, DEK, and SRm160 on the spliced mRNA, and inhibits ATP turnover by eIF4AIII, thereby trapping the EJC core onto RNA [[cite:PUB00029696], [cite:PUB00051821]].</p> <p>RBM8 contains an N-terminal putative bipartite nuclear localization signal, one RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), in the central region, and a C-terminal serine-arginine rich region (SR domain) and glycine-arginine rich region (RG domain) [[cite:PUB00010370]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | MRNA binding | Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: RNA-binding protein 8A-like [Glycine max] gi|356497345|ref|XP_003517521.1| | 13 | ||
| – | RNA-binding family protein; TAIR: AT1G51510.1 RNA-binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|B5DGI7|RBM8A_SALSA RNA-binding protein 8A; TrEMBL-Plants: tr|V7CI74|V7CI74_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0443800 | 15 | ||
| – | RNA-binding family protein; TAIR: AT1G51510.1 RNA-binding (RRM/RBD/RNP motifs) family protein; Swiss-Prot: sp|B5DGI7|RBM8A_SALSA RNA-binding protein 8A; TrEMBL-Plants: tr|V7CI74|V7CI74_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0443800 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |