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IPR008176

Source: InterPro

Description

IPR008176 is a Defensin, plant.

<p>The following small plant proteins are evolutionary related:</p> <ul> <li>Gamma-thionins from Triticum aestivum (Wheat) endosperm (gamma-purothionins) and gamma-hordothionins from Hordeum vulgare(Barley) are toxic to animal cells and inhibit protein synthesis in cell free systems [[cite:PUB00000384]].</li> <li>A flower-specific thionin (FST) from Nicotiana tabacum (Common Tobacco)[[cite:PUB00003753]].</li> <li>Antifungal proteins (AFP) from the seeds of Brassicaceae species such as radish, mustard, turnip and Arabidopsis thaliana (Thale Cress)[[cite:PUB00001650]].</li> <li>Inhibitors of insect alpha-amylases from sorghum [[cite:PUB00001598]].</li> <li>Probable protease inhibitor P322 from Solanum tuberosum (Potato).</li> <li>A germination-related protein from Vigna unguiculata (Cowpea) [[cite:PUB00004542]].</li> <li>Anther-specific protein SF18 from sunflower. SF18 is a protein that contains a gamma-thionin domain at its N terminus and a proline-rich C-terminal domain.</li> <li>Glycine max (Soybean) sulphur-rich protein SE60 [[cite:PUB00004576]].</li> <li>Vicia faba (Broad bean) antibacterial peptides fabatin-1 and -2.</li> </ul> <p>In their mature form, these proteins generally consist of about 45 to 50 amino-acid residues. As shown in the following schematic representation, these peptides contain eight conserved cysteines involved in disulphide bonds.</p> <pre> +-------------------------------------------+ | +-------------------+ | | | | | xxCxxxxxxxxxxCxxxxxCxxxCxxxxxxxxxCxxxxxxCxCxxxC | | | | +---|----------------+ | +------------------+ </pre> <p>'C': conserved cysteine involved in a disulphide bond.</p> <p>The folded structure of Gamma-purothionin is characterised by a well-defined 3-stranded anti-parallel β-sheet and a short α-helix [[cite:PUB00000384]]. Three disulphide bridges are located in the hydrophobic core between the helix and sheet, forming a cysteine-stabilised α-helical motif. This structure differs from that of the plant alpha- and beta-thionins, but is analogous to scorpion toxins and insect defensins.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006952
Biological process Defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
Subterm of

Associated Lotus transcripts 7

Transcript Name Description Predicted domains Domain count
Lj0g3v0253209.1
– Defensin precursor [Vigna unguiculata] gi|225548306|gb|ACN93800.1|
Domains
18
Lj0g3v0276939.1
– Scorpion toxin-like knottin superfamily protein [Theobroma cacao] gi|508712956|gb|EOY04853.1|
Domains
17
Lj1g3v1382030.1
– PREDICTED: defensin-like protein 6-like [Glycine max] gi|356516435|ref|XP_003526900.1|
Domains
17
Lj3g3v0720000.1
– PREDICTED: defensin-like protein 19-like [Cicer arietinum] gi|502155954|ref|XP_004510254.1|
Domains
16
Lj4g3v2858510.1
– Scorpion toxin-like knottin superfamily protein [Theobroma cacao] gi|508712956|gb|EOY04853.1|
Domains
17
LotjaGi1g1v0328600_LC.1
– Defensin-like family protein; TAIR: AT5G63660.1 Scorpion toxin-like knottin superfamily protein; Swiss-Prot: sp|Q9FFP8|DEF06_ARATH Defensin-like protein 6; TrEMBL-Plants: tr|A0A061EJM1|A0A061EJM1_THECC Scorpion toxin-like knottin superfamily protein; Found in the gene: LotjaGi1g1v0328600_LC
Domains
17
LotjaGi3g1v0086300_LC.1
– Defensin-like protein; TAIR: AT1G19610.1 defensin-like protein; Swiss-Prot: sp|P82787|DEF19_ARATH Defensin-like protein 19; TrEMBL-Plants: tr|A0A072TL50|A0A072TL50_MEDTR Defensin-like protein; Found in the gene: LotjaGi3g1v0086300_LC
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd00107 CDD 1 14.29