Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR008501

Source: InterPro

Description

IPR008501 is a THO complex subunit 7/Mft1.

<p>The THO complex (THOC) is involved in transcription elongation and mRNA export from the nucleus [[cite:PUB00044694]]. This entry represents the subunit THOC7, which is found in higher eukaryotes, and the non-homologous subunit Mft1 found in yeast.</p> <p>Mft1 is a component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export [[cite:PUB00044998]]. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription [[cite:PUB00063151]]. THO is important for stabilising nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase [[cite:PUB00063152]]. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase Sub2 and the mRNA export factor Yra1 along the nascent mRNA [[cite:PUB00063153]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0000445
Cellular component THO complex part of transcription export complex The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.
Subterm of
Part of
GO:0006397
Biological process MRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj6g3v1995980.1
– PREDICTED: THO complex subunit 7 homolog isoform X1 [Cicer arietinum] gi|502078212|ref|XP_004485873.1|
Domains
5
LotjaGi6g1v0324900.1
– THO complex subunit 7 like; TAIR: AT5G16790.1 Tho complex subunit 7/Mft1p; Swiss-Prot: sp|Q8LDS5|THO7A_ARATH THO complex subunit 7A; TrEMBL-Plants: tr|A0A0L9VF74|A0A0L9VF74_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0324900
Domains
6

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00